{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T12:58:22Z","timestamp":1761310702072},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,5,20]],"date-time":"2011-05-20T00:00:00Z","timestamp":1305849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["RO1 NS31718"],"award-info":[{"award-number":["RO1 NS31718"]}]},{"name":"Mental Retardation Developmental Disorders Research Center","award":["P30 HD18655"],"award-info":[{"award-number":["P30 HD18655"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The <jats:italic>N<\/jats:italic>\u2010methyl\u2010<jats:sc>d<\/jats:sc>\u2010aspartate glutamate receptor (NMDAR) has been implicated in preterm brain injury (periventricular leukomalacia (PVL)) and represents a potential therapeutic target. However, the antagonist dizocilpine (MK\u2010801) has been reported to increase constitutive neuronal apoptosis in the developing rat brain, limiting its clinical use in the developing brain. Memantine is another use\u2010dependent NMDAR antagonist with shorter binding kinetics and has been demonstrated to be protective in a rat model of PVL, without effects on normal myelination or cortical growth. To further evaluate the safety of memantine in the developing brain, we demonstrate here that, in contrast to MK\u2010801, memantine at neuroprotective doses does not increase neuronal constitutive apoptosis. In addition, there are no long\u2010term alterations in the expression of NMDAR subunits, AMPAR subunits, and two markers of synaptogenesis, Synapsin\u20101 and PSD95. Evaluating clinically approved drugs in preclinical neonatal animal models of early brain development is an important prerequisite to considering them for clinical trial in preterm infants and early childhood.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2011.05.005","type":"journal-article","created":{"date-parts":[[2011,5,23]],"date-time":"2011-05-23T05:07:27Z","timestamp":1306127247000},"page":"767-773","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The clinically available NMDA receptor antagonist, memantine, exhibits relative safety in the developing rat brain"],"prefix":"10.1002","volume":"29","author":[{"given":"Simon M.","family":"Manning","sequence":"first","affiliation":[{"name":"Department of Neurology Children's Hospital Boston and Harvard Medical School Boston MA 02115 USA"},{"name":"Division of Newborn Medicine Brigham and Women's Hospital Boston MA 02115 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Griffin","family":"Boll","sequence":"additional","affiliation":[{"name":"Department of Neurology Children's Hospital Boston and Harvard Medical School Boston MA 02115 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erin","family":"Fitzgerald","sequence":"additional","affiliation":[{"name":"Department of Neurology Children's Hospital Boston and Harvard Medical School Boston MA 02115 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debra B.","family":"Selip","sequence":"additional","affiliation":[{"name":"Department of Neurology Children's Hospital Boston and Harvard Medical School Boston MA 02115 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph J.","family":"Volpe","sequence":"additional","affiliation":[{"name":"Department of Neurology Children's Hospital Boston and Harvard Medical School Boston MA 02115 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frances E.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Neurology Children's Hospital Boston and Harvard Medical School Boston MA 02115 USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,5,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.222550499"},{"issue":"3","key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/0014-2999(89)90385-3","article-title":"Memantine is a potent blocker of N\u2010methyl\u2010d, \u2010aspartate (NMDA) receptor channels","volume":"166","author":"Bormann J.","year":"1989","journal-title":"Eur. 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