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This disorder is characterized by reduction in brain size, cognitive deficits and emotional\/social disturbances. These alterations are thought to be caused by an alcohol\u2010induced increase in apoptosis during neurodevelopment. Little is known about neuroapoptosis in the central extended amygdala and the pyriform cortex, which are key structures in emotional\/social behaviors. The goal of this study was to determine the vulnerability of neuroapoptotic alcohol effects in those areas. Rats were administered alcohol (2.5 g\/kg s.c. at 0 and 2 h) or saline on postnatal day (PND) 7, 15 and 20. The Amino\u2010cupric\u2010silver technique was used to evaluate neurodegeneration and immunohistochemistry to detect activated caspases 3\u20138 and 9 at 2 h, 4, 6, 8, 12 and 24 h after drug administration. We measured blood alcohol levels each hour, from 2 to 8 h post second administration of alcohol in each of the ages studied. Results showed alcohol induced apoptotic neurodegeneration in the central extended amygdala on PND 7 and 15, and pyriform cortex on PND 7, 15 and 20. These structures showed activation of caspase 3 and 9 but not of caspase 8 suggesting that alcohol\u2010induced apoptosis could occur by the intrinsic pathway. The pharmacokinetic differences between ages did not associate with the neurodegeneration age dependence. In conclusion, these limbic areas are damaged by alcohol, and each one has their own window of vulnerability during the postnatal period. The possible implications in emotional\/social features in FASD are discussed.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2011.05.011","type":"journal-article","created":{"date-parts":[[2011,6,13]],"date-time":"2011-06-13T04:12:02Z","timestamp":1307938322000},"page":"733-742","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Alcohol\u2010induced neuronal death in central extended amygdala and pyriform cortex during the postnatal period of the rat"],"prefix":"10.1002","volume":"29","author":[{"given":"V.","family":"Balaszczuk","sequence":"first","affiliation":[{"name":"Instituto de Investigaci\u00f3n M\u00e9dica Mercedes y Mart\u00edn Ferreyra Friuli 2434 5016 C\u00f3rdoba Argentina"},{"name":"Departamento de Biolog\u00eda Evolutiva Humana, Facultad de Psicolog\u00eda Universidad Nacional de C\u00f3rdoba 5000 C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bender","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n M\u00e9dica Mercedes y Mart\u00edn Ferreyra Friuli 2434 5016 C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.L.","family":"Pereno","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Evolutiva Humana, Facultad de Psicolog\u00eda Universidad Nacional de C\u00f3rdoba 5000 C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.A.","family":"Beltramino","sequence":"additional","affiliation":[{"name":"Instituto de Investigaci\u00f3n M\u00e9dica Mercedes y Mart\u00edn Ferreyra Friuli 2434 5016 C\u00f3rdoba Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,6,3]]},"reference":[{"issue":"1","key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.neulet.2006.05.039","article-title":"Effect of N\u2010methyl\u2010d, \u2010aspartate receptor blockade on caspase activation and neuronal death in the developing rat cerebellum","volume":"404","author":"Alavez S.","year":"2006","journal-title":"Neurosci. 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