{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:01:16Z","timestamp":1790424076532,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2011,7,18]],"date-time":"2011-07-18T00:00:00Z","timestamp":1310947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21591338"],"award-info":[{"award-number":["21591338"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Most patients with Rett syndrome (RTT) have both gastrointestinal problems and somatic growth failure, including microcephaly. Ghrelin is a peptide hormone involved in growth hormone secretion, interdigestive motility, and feeding behavior. Plasma ghrelin assays have previously been described for other neurodevelopmental disorders. To examine the pathophysiology of RTT, we measured plasma levels of ghrelin in patients with RTT. A case\u2013control study examining plasma levels of ghrelin, serum growth hormone, and insulin\u2010like growth factor\u20101 (IGF\u20101) was performed on 27 patients with RTT and 53 controls. Plasma levels of total (T)\u2010 and octanoyl (O)\u2010ghrelin were significantly lower in patients with RTT than in controls. Plasma levels of T\u2010ghrelin correlated significantly with serum IGF\u20101 levels and head circumference. Significantly lower levels of plasma T\u2010ghrelin and O\u2010ghrelin were observed in RTT patients with eating difficulties, while lower levels of plasma T\u2010ghrelin were observed in RTT patients with constipation, in comparison to patients without either of these symptoms. Alterations in plasma ghrelin levels may reflect various clinical symptoms and signs in RTT patients, including growth failure, acquired microcephalus, autonomic nerve dysfunction, and feeding difficulties. We describe the role of ghrelin in RTT and suggest this peptide as a novel biological marker in patients with RTT.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2011.07.003","type":"journal-article","created":{"date-parts":[[2011,7,23]],"date-time":"2011-07-23T12:52:30Z","timestamp":1311425550000},"page":"899-902","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Ghrelin levels are reduced in Rett syndrome patients with eating difficulties"],"prefix":"10.1002","volume":"29","author":[{"given":"Munetsugu","family":"Hara","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Child Health Kurume University School of Medicine Kurume Fukuoka 830\u20100011 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Nishi","sequence":"additional","affiliation":[{"name":"Department of Physiology Kurume University School of Medicine Kurume Fukuoka 830\u20100011 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