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Female littermates were either single\u2010caged (social isolation) or group\u2010caged (control) from postnatal day 28, and then subjected to behavioral sessions during postnatal day 50\u201353. Body weight gain of the isolates was accelerated during the experimental period and food intake was persistently greater than group\u2010caged controls from postnatal day 35. Isolated females showed a selective increase in cookie intake when they had additional cookie access to standard chow. The isolates exhibited hyperactivity with increased ambulatory counts and rearings during the activity test as compared with group\u2010caged controls. Behavioral scores of the elevated plus maze test did not differ between the isolates and group\u2010caged controls; however, immobility time during the forced swim test was significantly increased in the isolates. Basal levels of plasma corticosterone were elevated, but the corticosterone increase responding to an acute stress was blunted, in the isolates compared with group\u2010caged ones. 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