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Wistar rats received subcutaneous administration of homocysteine or saline (control) from the 6th to 29th day of life. The physical exercise was performed from the 30th to 60th day of life; 12 h after the last exercise session animals were sacrificed and the cerebral cortex was dissected out. It is shown that homocysteine reduces glutamate uptake increases thiobarbituric acid\u2010reactive substances and disrupts enzymatic antioxidant defenses in cerebral cortex. Physical activity reversed the homocysteine effects on glutamate uptake and on antioxidant enzymes activities; although the increase in thiobarbituric acid\u2010reactive substances was only partially reversed by exercise. These findings allow us to suggest that physical exercise may have a protective role against homocysteine\u2010induced oxidative imbalance and brain damage to the glutamatergic system.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2012.01.001","type":"journal-article","created":{"date-parts":[[2012,1,10]],"date-time":"2012-01-10T00:06:55Z","timestamp":1326154015000},"page":"69-74","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Physical exercise reverses glutamate uptake and oxidative stress effects of chronic homocysteine administration in the rat"],"prefix":"10.1002","volume":"30","author":[{"given":"Maira J.","family":"da Cunha","sequence":"first","affiliation":[{"name":"Departamento de Bioqu\u00edmica Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade Universidade Federal do Rio Grande do Sul Porto Alegre RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline A.","family":"da 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