{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:47:33Z","timestamp":1790718453804,"version":"4.1.0"},"reference-count":74,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2012,2,2]],"date-time":"2012-02-02T00:00:00Z","timestamp":1328140800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["P01HD57853"],"award-info":[{"award-number":["P01HD57853"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Within the last decade several genes have been identified as candidate risk genes for developmental dyslexia. Recent research using animal models and embryonic RNA interference (RNAi) has shown that a subset of the candidate dyslexia risk genes\u2014\n                    <jats:italic>DYX1C1, ROBO1, DCDC2, KIAA0319<\/jats:italic>\n                    \u2014regulate critical parameters of neocortical development, such as neuronal migration. For example, embryonic disruption of the rodent homolog of\n                    <jats:italic>DYX1C1<\/jats:italic>\n                    disrupts neuronal migration and produces deficits in rapid auditory processing (RAP) and working memory\u2014phenotypes that have been reported to be associated with developmental dyslexia. In the current study we used a modified prepulse inhibition paradigm to assess acoustic discrimination abilities of male Wistar rats following\n                    <jats:italic>in utero<\/jats:italic>\n                    RNA interference targeting\n                    <jats:italic>Kiaa0319<\/jats:italic>\n                    . We also assessed spatial learning and working memory using a Morris water maze (MWM) and a radial arm water maze. We found that embryonic interference with this gene resulted in disrupted migration of neocortical neurons leading to formation of heterotopia in white matter, and to formation of hippocampal dysplasia in a subset of animals. These animals displayed deficits in processing complex acoustic stimuli, and those with hippocampal malformations exhibited impaired spatial learning abilities. No significant impairment in working memory was detected in the\n                    <jats:italic>Kiaa0319<\/jats:italic>\n                    RNAi treated animals. Taken together, these results suggest that\n                    <jats:italic>Kiaa0319<\/jats:italic>\n                    plays a role in neuronal migration during embryonic development, and that early interference with this gene results in an array of behavioral deficits including impairments in rapid auditory processing and simple spatial learning.\n                  <\/jats:p>","DOI":"10.1016\/j.ijdevneu.2012.01.009","type":"journal-article","created":{"date-parts":[[2012,2,3]],"date-time":"2012-02-03T01:31:23Z","timestamp":1328232683000},"page":"293-302","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Neocortical disruption and behavioral impairments in rats following\n                    <i>in utero<\/i>\n                    RNAi of candidate dyslexia risk gene\n                    <i>Kiaa0319<\/i>"],"prefix":"10.1002","volume":"30","author":[{"given":"Caitlin E.","family":"Szalkowski","sequence":"first","affiliation":[{"name":"Department of Psychology\/Behavioral Neuroscience University of Connecticut 406 Babbidge Road, Unit 1020 Storrs CT 06269 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Fiondella","sequence":"additional","affiliation":[{"name":"Department of Physiology and Neurobiology University of Connecticut 75 North Eagleville Road Storrs CT 06269 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert M.","family":"Galaburda","sequence":"additional","affiliation":[{"name":"Department of Neurology Beth Israel Deaconess Medical Center 330 Brookline Ave. Boston MA 02215 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn D.","family":"Rosen","sequence":"additional","affiliation":[{"name":"Department of Neurology Beth Israel Deaconess Medical Center 330 Brookline Ave. Boston MA 02215 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph J.","family":"LoTurco","sequence":"additional","affiliation":[{"name":"Department of Physiology and Neurobiology University of Connecticut 75 North Eagleville Road Storrs CT 06269 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Holly","family":"Fitch","sequence":"additional","affiliation":[{"name":"Department of Psychology\/Behavioral Neuroscience University of Connecticut 406 Babbidge Road, Unit 1020 Storrs CT 06269 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,2,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1153"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1385\/JMN:27:3:311"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2005.06.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207450903275129"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2009.04419.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2010.12.020"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0104-56872010000400030"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.01.020"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7939663"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7777847"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0742-07.2008"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2005.09.016"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/dys.323"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/429131"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/YPG.0b013e32832080e1"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-004-1126-6"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10519-010-9434-1"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(00)00212-4"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1086\/302190"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn936"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2006.04.003"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.111.2.404"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1177\/1534582303258736"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2007.07.013"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/1744-9081-4-45"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617700644016"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1086\/426404"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devbrainres.2004.06.007"},{"key":"e_1_2_8_30_1","first-page":"295","article-title":"Neural correlates of rapid auditory processing are disrupted in children with developmental dyslexia and ameliorated with training: an fMRI study","volume":"25","author":"Gaab N.","year":"2007","journal-title":"Restor. Neurol. Neurosci."},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410180210"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jecp.2005.08.003"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1207\/S15326942DN2002_3"},{"key":"e_1_2_8_34_1","first-page":"27","article-title":"Susceptibility loci for distinct components of developmental dyslexia on chromosomes 6 and 15","volume":"60","author":"Grigorenko E.L.","year":"1997","journal-title":"Am. J. Hum. Genet."},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e3283292414"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0010050"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001904"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/7.5.453"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/dys.278"},{"key":"e_1_2_8_40_1","doi-asserted-by":"crossref","first-page":"5.1","DOI":"10.1146\/annurev-genom-090810-183119","article-title":"Genetics of speech and language disorders","volume":"12","author":"Kang C.","year":"2011","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.4065\/76.11.1081"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/dys.349"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.31135"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp033"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.03.007"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201356"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2006.00291.x"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0508591102"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2009.11.003"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/87565641.2010.549868"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10519-010-9424-3"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl089"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.8.080706.092312"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2008.07121872"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200212030-00021"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devbrainres.2003.09.020"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp154"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30787"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1051\/jbio\/2010009"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11689-009-9031-x"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhl162"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.16.2007"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2004.018341"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013712"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1080\/09658210601043384"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2010.00662.x"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1833911100"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/241468a0"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2006.11.005"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2010.12.015"},{"key":"e_1_2_8_71_1","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00335-007-9051-3","article-title":"Alternative splicing in the dyslexia\u2010associated gene KIAA0319","volume":"9","author":"Velayos\u2010Baeza A.","year":"2007","journal-title":"Mamm. Genome"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm358"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.145961"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.08.022"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1097\/DBP.0b013e3181ef42a1"}],"container-title":["International Journal of Developmental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073657481200010X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073657481200010X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijdevneu.2012.01.009","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2012.01.009","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.ijdevneu.2012.01.009","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2012.01.009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T22:16:45Z","timestamp":1694038605000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.ijdevneu.2012.01.009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,2,2]]},"references-count":74,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,6]]}},"alternative-id":["10.1016\/j.ijdevneu.2012.01.009"],"URL":"https:\/\/doi.org\/10.1016\/j.ijdevneu.2012.01.009","archive":["Portico"],"relation":{},"ISSN":["0736-5748","1873-474X"],"issn-type":[{"value":"0736-5748","type":"print"},{"value":"1873-474X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,2,2]]},"assertion":[{"value":"2011-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-01-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-02-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}