{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T04:00:34Z","timestamp":1773806434574,"version":"3.50.1"},"reference-count":60,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T00:00:00Z","timestamp":1336953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"NIH","award":["AA13023"],"award-info":[{"award-number":["AA13023"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>There is growing evidence that deficits in neuronal plasticity underlie the cognitive problems seen in fetal alcohol spectrum disorders (FASD). However, the mechanisms behind these deficits are not clear. Here we test the effects of early alcohol exposure on ocular dominance plasticity (ODP) in mice and the reversibility of these effects by phosphodiesterase (PDE) inhibitors. Mouse pups were exposed to 5 g\/kg of 25% ethanol i.p. on postnatal days (P) 5, 7 and 9. This type of alcohol exposure mimics binge drinking during the third trimester equivalent of human gestation. To assess ocular dominance plasticity animals were monocularly deprived at P21 for 10 days, and tested using optical imaging of intrinsic signals. During the period of monocular deprivation animals were treated with vinpocetine (20 mg\/kg; PDE1 inhibitor), rolipram (1.25 mg\/kg; PDE4 inhibitor), vardenafil (3 mg\/kg; PDE5 inhibitor) or vehicle solution. Monocular deprivation resulted in the expected shift in ocular dominance of the binocular zone in saline controls but not in the ethanol group. While vinpocetine successfully restored ODP in the ethanol group, rolipram and vardenafil did not. However, when rolipram and vardenafil were given simultaneously ODP was restored. PDE4 and PDE5 are specific to cAMP and cGMP respectively, while PDE1 acts on both of these nucleotides. Our findings suggest that the combined activation of the cAMP and cGMP cascades may be a good approach to improve neuronal plasticity in FASD models.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2012.05.001","type":"journal-article","created":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T07:49:18Z","timestamp":1336981758000},"page":"351-357","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Early alcohol exposure disrupts visual cortex plasticity in mice"],"prefix":"10.1002","volume":"30","author":[{"given":"Crystal L.","family":"Lantz","sequence":"first","affiliation":[{"name":"Department of Anatomy and Neurobiology School of Medicine Virginia Commonwealth University Richmond VA 23298 United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weili","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology School of Medicine Virginia Commonwealth University Richmond VA 23298 United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre E.","family":"Medina","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology School of Medicine Virginia Commonwealth University Richmond VA 23298 United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,5,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-11-04388.1999"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/2836"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.25.15020"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1523\/JNEUROSCI.10-03-00909.1990","article-title":"Disruption of experience\u2010dependent synaptic modifications in striate cortex by infusion of an NMDA receptor antagonist","volume":"10","author":"Bear M.F.","year":"1990","journal-title":"Journal of Neuroscience"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1995.75.4.725"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-009-8072-1"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523805225178"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-1943-3"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(87)90552-1"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.12.001"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.03.013"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5656-08.2010"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.02.046"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90394-8"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.12.003"},{"issue":"1","key":"e_1_2_6_17_1","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0014-2999(01)00900-1","article-title":"Effects of phosphodiesterase inhibitors on hypoxic pulmonary vasoconstriction. Influence of K (+) channels and nitric oxide","volume":"417","author":"Goirand F.","year":"2001","journal-title":"European Journal of Pharmacology"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1998.tb03653.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004850-199100610-00005"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.287.5455.1056"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161210790963760"},{"issue":"4","key":"e_1_2_6_22_1","doi-asserted-by":"crossref","first-page":"I20","DOI":"10.1002\/clc.4960271306","article-title":"Novel phosphodiesterase type 5 inhibitors, assessing hemodynamic effects and safety parameters","volume":"27","author":"Kloner R.A.","year":"2004","journal-title":"Clinical Cardiology"},{"issue":"3","key":"e_1_2_6_23_1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1530-0277.2009.01114.x","article-title":"Phosphodiesterase type 4 inhibition does not restore ocular dominance plasticity in a ferret model of fetal alcohol spectrum disorders","volume":"34","author":"Krahe T.E.","year":"2010","journal-title":"Alcohol Clin Exp Res"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(02)00873-0"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00828-0"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.25.112701.142758"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddrr.68"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21447"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devbrainres.2005.03.012"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4177-05.2006"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00714.2004"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-31-10002.2003"},{"issue":"8","key":"e_1_2_6_33_1","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nrd2058","article-title":"Phosphodiesterases in the CNS: targets for drug development","volume":"5","author":"Menniti F.S.","year":"2006","journal-title":"Nature Reviews Drug Discovery"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00247312"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.2063611"},{"issue":"6","key":"e_1_2_6_36_1","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3109\/15563658909000358","article-title":"Severe alcohol intoxication: a study of 204 consecutive patients","volume":"27","author":"Minion G.E.","year":"1989","journal-title":"Journal of Toxicology \u2013 Clinical Toxicology"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(92)90602-Z"},{"key":"e_1_2_6_38_1","first-page":"255","article-title":"The impairment of long\u2010term potentiation in rats with medial septal lesion and its restoration by cognition enhancers","volume":"2","author":"Molnar P.","year":"1994","journal-title":"Neurobiology (Bp)"},{"key":"e_1_2_6_39_1","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1523\/JNEUROSCI.22-06-02237.2002","article-title":"cAMP\/Ca2 response element\u2010binding protein function is essential for ocular dominance plasticity","volume":"22","author":"Mower A.F.","year":"2002","journal-title":"The Journal of Neuroscience"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.5"},{"issue":"1","key":"e_1_2_6_41_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.drugalcdep.2011.05.024","article-title":"Acute administration of vinpocetine, a phosphodiesterase type 1 inhibitor, ameliorates hyperactivity in a mice model of fetal alcohol spectrum disorder","volume":"119","author":"Nunes F.","year":"2011","journal-title":"Drug and Alcohol Dependence"},{"issue":"3","key":"e_1_2_6_42_1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1161\/01.RES.0000256354.95791.f1","article-title":"Overview of PDEs and their regulation","volume":"100","author":"Omori K.","year":"2007","journal-title":"Circulation Research"},{"issue":"3","key":"e_1_2_6_43_1","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/S1734-1140(11)70574-6","article-title":"Role of vinpocetine in cerebrovascular diseases","volume":"63","author":"Patyar S.","year":"2011","journal-title":"Pharmacological Reports"},{"key":"e_1_2_6_44_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5840-09.2010"},{"key":"e_1_2_6_45_1","doi-asserted-by":"publisher","DOI":"10.2741\/1616"},{"key":"e_1_2_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(02)00199-9"},{"key":"e_1_2_6_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/09297040600646854"},{"key":"e_1_2_6_48_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-24-10993.1999"},{"key":"e_1_2_6_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30014"},{"key":"e_1_2_6_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2005.09.002"},{"issue":"1","key":"e_1_2_6_51_1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ejphar.2006.11.041","article-title":"Time\u2010dependent involvement of cAMP and cGMP in consolidation of object memory: studies using selective phosphodiesterase type 2, 4 and 5 inhibitors","volume":"558","author":"Rutten K.","year":"2007","journal-title":"European Journal of Pharmacology"},{"key":"e_1_2_6_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-007-0999-1"},{"key":"e_1_2_6_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.24"},{"key":"e_1_2_6_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2002.tb02480.x"},{"key":"e_1_2_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.09.016"},{"key":"e_1_2_6_56_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2008.0198"},{"key":"e_1_2_6_57_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.121.1.120"},{"key":"e_1_2_6_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301496"},{"key":"e_1_2_6_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2327"},{"key":"e_1_2_6_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130000414"},{"key":"e_1_2_6_61_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.9.6.1283"}],"container-title":["International Journal of Developmental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736574812003978?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736574812003978?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijdevneu.2012.05.001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2012.05.001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.ijdevneu.2012.05.001","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2012.05.001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T02:18:53Z","timestamp":1694053133000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.ijdevneu.2012.05.001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,14]]},"references-count":60,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["10.1016\/j.ijdevneu.2012.05.001"],"URL":"https:\/\/doi.org\/10.1016\/j.ijdevneu.2012.05.001","archive":["Portico"],"relation":{},"ISSN":["0736-5748","1873-474X"],"issn-type":[{"value":"0736-5748","type":"print"},{"value":"1873-474X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,14]]},"assertion":[{"value":"2012-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-05-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-05-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}