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Since MK\u2010801, an antagonist of N\u2010methyl\u2010<jats:sc>d<\/jats:sc>\u2010aspartate (NMDA) receptor, showed many adverse reactions that hampered its clinical applications, development of safe and effective agent for the treatment of cerebral ischemia is eagerly required. This study was to investigate the effects of N<jats:sup>1<\/jats:sup>\u2010(quinolin\u20102\u2010ylmethyl)butane\u20101,4\u2010diamine (QMA), a polyamine analogue, on the in vitro and in vivo models of cerebral ischemic damage. The results revealed that pretreatment with QMA could attenuate Glu, putrescine (Put) and oxygen\u2010glucose deprivation (OGD)\u2010induced cell death, lipid peroxidation as well as the elevation of reactive oxygen species (ROS) and intracellular [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> in pheochromocytoma (PC12) cells and in rat primary cortical neurons. The results also demonstrated that QMA could inhibit NMDA\u2010mediated intracellular [Ca<jats:sup>2+<\/jats:sup>]<jats:sub>i<\/jats:sub> accumulation in rat primary cortical neurons and reduce brain infarct volume in middle cerebral artery occlusion (MCAO) rats. The present report suggested that polyamines played a crucial role in the pathological processes of cerebral ischemic damage and that QMA or other novel polyamine analogues could be promising therapeutic candidates for stroke by virtue of their anti\u2010hypoxia and antioxidation property.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2012.08.008","type":"journal-article","created":{"date-parts":[[2012,9,11]],"date-time":"2012-09-11T20:06:12Z","timestamp":1347393972000},"page":"584-595","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["N<sup>1<\/sup>\u2010(quinolin\u20102\u2010ylmethyl)butane\u20101,4\u2010diamine, a polyamine analogue, attenuated injury in in vitro and in vivo models of cerebral ischemia"],"prefix":"10.1002","volume":"30","author":[{"given":"Juan","family":"Cen","sequence":"first","affiliation":[{"name":"Key Laboratory of Natural Medicine and Immune Engineering Henan University Kaifeng 475004 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