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Altered protein expression profiles associated with IUGR may be informative on the pathological mechanisms of this condition and might reveal potential markers for postnatal complications. We hypothesized that nutrient manipulation of the pregnant rat might influence the expression of important neurodevelopmental proteins in the resultant IUGR offspring. Therefore, we aimed to determine in newborn rat brain tissue the expression of collapsin response mediator proteins (CRMPs)\u20101, \u20102 and \u20105, commonly referred to as dihydropyrimidinase\u2010related proteins (DPYLs) \u2013 playing a role in axon guidance, invasive growth and cell migration \u2013 and compare it to the corresponding expression in control rats. Two\u2010dimensional electrophoresis and mass spectrometry, as well as Western blot analysis were employed in brain tissue from 24 IUGR newborn rats and 24 controls. With both methods, CRMP\u20101, CRMP\u20102 and CRMP\u20105 were decreased in the brains of the IUGR group as compared to the control group at the time of delivery. In conclusion, IUGR rat offspring are born with a decreased expression of CRMPs, suggesting that these proteins may be implicated in fetal stress\u2010induced programming.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2012.10.004","type":"journal-article","created":{"date-parts":[[2012,10,18]],"date-time":"2012-10-18T08:05:14Z","timestamp":1350547514000},"page":"53-60","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Aberrant expression of collapsin response mediator proteins\u20101, \u20102 and \u20105 in the brain of intrauterine growth restricted rats"],"prefix":"10.1002","volume":"31","author":[{"given":"Eftychia","family":"Aravidou","sequence":"first","affiliation":[{"name":"First Department of Pediatrics Medical School University of Athens Aghia Sophia Children's Hospital Thivon &amp; Papadiamantopoulou str. 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