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FDG\u2010PET studies show that the cerebral metabolic rate for glucose (CMRglc) declines dramatically with onset of BS in the adult brain. Global CMRglc increases substantially in the post\u2010natal period and achieves its maximum in preadolescence. However, the impact of post\u2010natal brain development on the vulnerability of CMRglc to the onset of BS has not been documented.<\/jats:p><jats:p>Therefore, cerebral blood flow and metabolism were measured using a variant of the Kety\u2013Schmidt method, in conjunction with quantitative regional estimation of brain glucose uptake by FDG\u2010PET in groups of neonate and juvenile pigs, under a condition of light sedation or after induction of deep anaesthesia with thiopental. Quantification of simultaneous ECoG recordings was used to establish the correlation between anaesthesia\u2010related changes in brain electrical activity and the observed cerebrometabolic changes.<\/jats:p><jats:p>In the condition of light sedation the magnitude of CMRglc was approximately 20% higher in the older pigs, with the greatest developmental increase evident in the cerebral cortex and basal ganglia (<jats:italic>P<\/jats:italic> &lt; 0.05). Onset of BS was associated with 20\u201340% declines in CMRglc. Subtraction of the mean parametric maps for CMRglc showed the absolute reductions in CMRglc evoked by thiopental anaesthesia to be two\u2010fold greater in the pre\u2010adolescent pigs than in the neonates (<jats:italic>P<\/jats:italic> &lt; 0.05). Thus, the lesser suppression of brain energy demand of neonate brain during deep anaesthesia represents a reduced part of thiopental suppressing brain metabolism in neonates.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2012.12.008","type":"journal-article","created":{"date-parts":[[2013,1,8]],"date-time":"2013-01-08T21:17:57Z","timestamp":1357679877000},"page":"157-164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Resistance of brain glucose metabolism to thiopental\u2010induced CNS depression in newborn piglets"],"prefix":"10.1002","volume":"31","author":[{"given":"Bernd","family":"Walter","sequence":"first","affiliation":[{"name":"Institute of Molecular Cell Biology Jena University Hospital Friedrich Schiller University Jena Germany"},{"name":"Department of Spinal Surgery und Neurotraumatology Heinrich\u2010Braun\u2010Hospital Zwickau 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