{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T01:52:43Z","timestamp":1775872363019,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T00:00:00Z","timestamp":1362441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neonatal hypoxia\u2010ischemia (HI) affects 60% of low birth weight infants and up to 40% of preterm births. Cell death and brain injury after HI have been shown to cause long\u2010lasting behavioral deficits. By using a battery of behavioral tests on second generation 3\u2010week\u2010old rodents, we found that neonatal HI is associated with behavioral outcomes in the progeny of HI\u2010affected parents. Our results suggest an epigenetic transfer mechanism of some of the neurological symptoms associated with neonatal HI. Elucidating the transfer of brain injury to the next generation after HI calls attention to the risks associated with HI injury and the need for proper treatment to reverse these effects. Assessing the devastating extent of HI's reach serves as a cautionary tale to the risks associated with neonatal HI, and provides an incentive to create improved therapeutic measures to treat HI.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2013.02.003","type":"journal-article","created":{"date-parts":[[2013,3,5]],"date-time":"2013-03-05T11:49:58Z","timestamp":1362484198000},"page":"398-405","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Transgenerational effects of neonatal hypoxia\u2010ischemia in progeny"],"prefix":"10.1002","volume":"31","author":[{"given":"Smitha K.","family":"Infante","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University of Texas Medical Branch Galveston TX 77555 United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harriett C.","family":"Rea","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University of Texas Medical Branch Galveston TX 77555 United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.R.","family":"Perez\u2010Polo","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University of Texas Medical Branch Galveston TX 77555 United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,3,5]]},"reference":[{"issue":"3","key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1148\/radiol.2393050027","article-title":"Term neonate prognoses after perinatal asphyxia: contributions of MR imaging, MR spectroscopy, relaxation times, and apparent diffusion coefficients","volume":"239","author":"Boichot C.","year":"2006","journal-title":"Radiology"},{"issue":"5","key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1002\/jnr.22273","article-title":"Normobaric hyperoximia increases hypoxia\u2010induced cerebral injury: DTI study in rats","volume":"88","author":"Bockhorst K.H.","year":"2010","journal-title":"Journal of Neuroscience Research"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.142.3596.1192"},{"issue":"1","key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1002\/neu.480030105","article-title":"Effects of environmental enrichment and impoverishment on rat cerebral cortex","volume":"3","author":"Diamond M.C.","year":"1972","journal-title":"Journal of Neurobiology"},{"issue":"4","key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.ijdevneu.2009.02.005","article-title":"Bax\u2010an emerging role in ectopic cell death","volume":"27","author":"Dicou E.","year":"2009","journal-title":"International Journal of Developmental Neuroscience"},{"issue":"11","key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.2217\/fon.12.126","article-title":"Personalized therapy for metastatic melanoma: could timing be everything?","volume":"8","author":"Dronca","year":"2012","journal-title":"Future Oncology"},{"key":"e_1_2_7_8_1","first-page":"262","article-title":"Hypoxia\u2010induced mitochondrial and nuclear DNA damage in the rat brain","volume":"58","author":"Englander E.W.","year":"1999","journal-title":"JNR"},{"issue":"4","key":"e_1_2_7_9_1","first-page":"H1809","article-title":"Perivascular nitric oxide and superoxide in neonatal cerebral hypoxia\u2010ischemia","volume":"295","author":"Fabian R.H.","year":"2008","journal-title":"American Journal of Physiology: Heart and Circulatory Physiology"},{"issue":"4","key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ijdevneu.2004.03.006","article-title":"Extracellular superoxide concentration increases following cerebral hypoxia but does not affect cerebral blood flow","volume":"22","author":"Fabian R.H.","year":"2004","journal-title":"International Journal of Developmental Neuroscience"},{"issue":"7","key":"e_1_2_7_11_1","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1002\/jnr.21253","article-title":"A decoy oligonucleotide inhibiting NF\u2010\u03baB binding to the IgG\u03baB consensus site reduces cerebral injury and apoptosis in neonatal hypoxic\u2010ischemic encephalopathy","volume":"85","author":"Fabian R.H.","year":"2007","journal-title":"Journal of Neuroscience Research"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22358"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064\u2010010\u20100308\u2010y"},{"issue":"16","key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"3584","DOI":"10.1002\/jnr.21795","article-title":"Bax shuttling after neonatal hypoxia\u2010ischemia: hyperoxia effects","volume":"86","author":"Gill M.B.","year":"2008","journal-title":"Journal of Neuroscience Research"},{"issue":"9","key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1002\/jnr.22019","article-title":"Bax shuttling after rotenone treatment of neuronal primary cultures: effects on cell death phenotypes","volume":"87","author":"Gill M.B.","year":"2009","journal-title":"Journal of Neuroscience Research"},{"issue":"12","key":"e_1_2_7_16_1","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1007\/s11064-008-9649-1","article-title":"Hypoxia ischemia\u2010mediated cell death in neonatal rat brain","volume":"33","author":"Gill M.B.","year":"2008","journal-title":"Neurochemical Research"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2011.02.014"},{"issue":"1","key":"e_1_2_7_18_1","first-page":"119","article-title":"Long\u2010term histological outcome after post\u2010hypoxic treatment with 100% or 40% oxygen in a model of perinatal hypoxic\u2010ischemic brain injury","volume":"26","author":"Grafe M.R.","year":"2008","journal-title":"IJDN"},{"key":"e_1_2_7_19_1","article-title":"Sex differences in mechanisms and outcome of neonatal hypoxia\u2010ischemia in rodent models: implications for sex\u2010specific neuroprotection in clinical neonatal practice","volume":"2012","author":"Hill C.A.","year":"2012","journal-title":"Neurology Research International"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2004.02968.x"},{"issue":"7","key":"e_1_2_7_21_1","first-page":"371","article-title":"Bcl\u20102 family members make different contributions to cell death in hypoxia and\/or hyperoxia in rat cerebral cortex","volume":"21","author":"Hu X.","year":"2003","journal-title":"IJDN"},{"issue":"9","key":"e_1_2_7_22_1","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1021\/pr060209x","article-title":"Proteomic analysis of hypoxia\/ischemia\u2010induced alteration of cortical development and dopamine neurotransmission in neonatal rat","volume":"5","author":"Xiaoming H.","year":"2006","journal-title":"Journal of Proteome Research"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1990.tb40490.x"},{"issue":"8","key":"e_1_2_7_24_1","first-page":"673","article-title":"Biphasic changes in the levels of poly(ADP\u2010ribose) polymerase\u20101 and caspase 3in the immature brain following hypoxia\u2010ischemia","volume":"23","author":"Martin S.S.","year":"2005","journal-title":"IJDN"},{"issue":"6","key":"e_1_2_7_25_1","first-page":"639","article-title":"Oxygen resuscitation after hypoxia ischemia stimulates prostaglandin pathway in rat cortex","volume":"29","author":"Perez\u2010Polo J.R.","year":"2011","journal-title":"IJDN"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.1070"},{"issue":"1","key":"e_1_2_7_27_1","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/jnr.20156","article-title":"Effects of NF\u2010\u03baB oligonucleotide \u201cDecoys\u201d on gene expression in p7 rat hippocampus after hypoxia\/ischemia","volume":"77","author":"Qiu J.","year":"2004","journal-title":"Journal of Neuroscience Research"},{"key":"e_1_2_7_28_1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/ana.410090206","article-title":"The influence of immaturity on hypoxic\u2010ischemic brain damage in the rat","volume":"9","author":"Rice J.E.","year":"1981","journal-title":"Annals of Neurology"},{"issue":"1","key":"e_1_2_7_29_1","first-page":"125","article-title":"The association of early blood oxygenation with child development in preterm infants with acute respiratory disorders","volume":"26","author":"Smith K.E.","year":"2008","journal-title":"IJDN"},{"issue":"1","key":"e_1_2_7_30_1","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.bbr.2004.11.018","article-title":"Postnatal caffeine exposure: effects on motor skills and locomotor activity during ontogenesis","volume":"160","author":"Tchekalarova J.","year":"2005","journal-title":"Behavioural Brain Research"},{"key":"e_1_2_7_31_1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1023\/A:1021656430576","article-title":"Hyperoxia increases AP\u20101 DNA binding in rat brain","volume":"28","author":"Tong L.Q.T.","year":"2003","journal-title":"Neurochemical Research"},{"key":"e_1_2_7_32_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1161\/01.STR.19.2.245","article-title":"Regional cerebral blood flow during hypoxia\u2010ischemia in immature rats","volume":"19","author":"Vannucci R.C.","year":"1988","journal-title":"Stroke"},{"issue":"2","key":"e_1_2_7_33_1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/(SICI)1097-4547(19990115)55:2<158::AID-JNR3>3.0.CO;2-1","article-title":"Title Rat model of perinatal hypoxic\u2010ischemic brain damage","volume":"55","author":"Vannucci R.C.","year":"1999","journal-title":"Journal of Neuroscience Research"},{"issue":"2","key":"e_1_2_7_34_1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/01.CCM.0000153931.23488.DD","article-title":"Gender associations with cerebrospinal fluid glutamate and lactate\/pyruvate levels after severe traumatic brain injury","volume":"33","author":"Wagner A.K.","year":"1995","journal-title":"Critical Care Medicine"},{"key":"e_1_2_7_35_1","unstructured":"S.A.Zanelli D.P.Stanley D.Kaufman.Hypoxic\u2013Ischemic Encephalopathy.2008http:\/\/emedicine.medscape.com\/article\/973501\u2010overview"}],"container-title":["International Journal of Developmental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736574813000294?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736574813000294?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijdevneu.2013.02.003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2013.02.003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.ijdevneu.2013.02.003","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2013.02.003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T21:46:05Z","timestamp":1715031965000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.ijdevneu.2013.02.003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3,5]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["10.1016\/j.ijdevneu.2013.02.003"],"URL":"https:\/\/doi.org\/10.1016\/j.ijdevneu.2013.02.003","archive":["Portico"],"relation":{},"ISSN":["0736-5748","1873-474X"],"issn-type":[{"value":"0736-5748","type":"print"},{"value":"1873-474X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,3,5]]},"assertion":[{"value":"2012-09-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-02-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-03-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}