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Many microorganisms, including certain viruses, protozoa, and bacteria, have been linked to this injury. In regard to the mechanisms of intrauterine infection\u2010triggered brain injury, the inflammatory risk factors such as cytokines play a central role. The inflammation signal is likely transmitted across the blood\u2013brain barrier and initiates a neuroinflammatory response. Studies have reported that polymorphism of cytokine genes also has been implicated in perinatal brain injury. Moreover, inflammation and HI may be synergistically involved in this process. Although the relationship between inflammation and adverse neurodevelopmental outcome in affected infants is slowly being elucidated, the literature contains scant evidence of measures that can improve fetal neurologic outcome. Several pharmacologic molecules such as magnesium sulphate, erythropoietin, and corticosteroids as a neuroprotective agent for the fetus need further investigation.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2013.06.008","type":"journal-article","created":{"date-parts":[[2013,7,3]],"date-time":"2013-07-03T20:29:33Z","timestamp":1372883373000},"page":"543-549","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Effect of intrauterine infection on brain development and injury"],"prefix":"10.1002","volume":"31","author":[{"given":"Jing","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Neonatology Affiliated Hospital of North Sichuan Medical College Nanchong 637000 China"},{"name":"Department of Pediatrics Affiliated Hospital of North Sichuan Medical College Nanchong 637000 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