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An enriched environment improves mental abilities in humans and animals. Whether an enriched environment can prevent the development of schizoid symptoms induced by neonatal NMDAR dysfunction was the central question of our paper. The experimental animals were Wistar rats. Early postnatal NMDAR dysfunction was created by systemic treatment of rat pups with the NMDAR antagonist MK\u2010801 at PD10\u201320 days. During the development period (PD21\u201390 days), the rats were reared in cognitively and physically enriched cages. Adult age rats were tested on navigation based on pattern separation and episodic memory in the open field and on auto\u2010hetero\u2010associations based on episodic and semantic memory in a step\u2010through passive avoidance task. The results showed that postnatal NMDAR antagonism caused abnormal behaviors in both tests. An enriched environment prevented deficits in the development of navigation in space based on pattern separation and hetero\u2010associations based on semantic memory. However, an enriched environment was unable to rescue navigation in space and auto\u2010associations based on episodic memory. These data may contribute to the understanding that an enriched environment has a limited capacity for therapeutic interventions in protecting the development of schizoid syndromes in children and adolescents.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2013.10.004","type":"journal-article","created":{"date-parts":[[2013,10,30]],"date-time":"2013-10-30T10:32:16Z","timestamp":1383129136000},"page":"22-28","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Enriched environment has limited capacity for the correction of hippocampal memory\u2010dependent schizoid behaviors in rats with early postnatal NMDAR dysfunction"],"prefix":"10.1002","volume":"33","author":[{"given":"Enver","family":"Melik","sequence":"first","affiliation":[{"name":"Department of Physiology Medical Faculty, University of \u00c7ukurova 01330 Balcal\u0131 Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emine","family":"Babar","sequence":"additional","affiliation":[{"name":"Department of Physiology Medical Faculty, University of \u00c7ukurova 01330 Balcal\u0131 Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sayad","family":"Kocahan","sequence":"additional","affiliation":[{"name":"Department of Physiology, Medical Faculty University of Adiyaman Adiyaman Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Guven","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Medical Faculty University of \u00c7ukurova 01330 Balcal\u0131 Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kubra","family":"Akillioglu","sequence":"additional","affiliation":[{"name":"Department of Physiology Medical Faculty, University of \u00c7ukurova 01330 Balcal\u0131 Adana Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,10,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.02.018"},{"issue":"1","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/nn.2447","article-title":"Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia\u2010like phenotypes","volume":"13","author":"Belforte J.E.","year":"2010","journal-title":"Nat. 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