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The protective activity of GPs during stroke and their effects on neural stem cells (NSCs) in the ischemic brain have not been fully elucidated. Here, we test the effects of GPs during stroke and on the NSCs within the subventricular zone (SVZ) of middle cerebral artery occlusion (MCAO) rats. Our results show that pre\u2010treatment with GPs can reduce infarct volume and improve motor function following MCAO. Pre\u2010treatment with GPs significantly increased the number of BrdU\u2010positive cells in the ipsilateral and contralateral SVZ of MCAO rats. The proliferating cells in both sides of the SVZ were glial fibrillary acidic protein (GFAP)\/nestin\u2010positive type B cells and doublecortin (DCX)\/nestin\u2010positive type A cells. Our data indicate that GPs have neuroprotective effects during stroke which might be mediated through the enhancement of neurogenesis within the SVZ. These findings provide new evidence for a potential therapy involving GPs for the treatment of stroke.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2013.12.001","type":"journal-article","created":{"date-parts":[[2013,12,13]],"date-time":"2013-12-13T01:32:24Z","timestamp":1386898344000},"page":"49-56","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Gypenosides pre\u2010treatment protects the brain against cerebral ischemia and increases neural stem cells\/progenitors in the subventricular zone"],"prefix":"10.1002","volume":"33","author":[{"given":"Xiao\u2010Jing","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cell Biology School of Medicine Shandong University Jinan Shandong People's Republic of China"},{"name":"Department of Neurobiology Shandong Provincial Key Laboratory of Mental Disorders School of Medicine Shandong University Jinan Shandong People's Republic of 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