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The aim of the present study was to evaluate the association between the AGEs level and neural tube defects (NTDs) occurrence risk. Forty\u2010eight mothers with NTD\u2010affected pregnancies and 50 normal mothers were selected in this study. Blood were collected from the mothers and were assayed for serum AGEs, malondiadehyde (MDA) and hemoglobin A1c (HbA1c). Data were analyzed by logistic regression method. The study indicated that there were significant but modest lower prevalence for cases mothers on age, BMI and glucose levels compared with controls. NTD\u2010affected mothers were significantly more likely to have higher AGEs levels (5.6 \u00b1 0.48 AU vs. 4.6 \u00b1 0.68 AU<jats:italic>\u03c1<\/jats:italic>&lt; 0.01) than controls. The AGEs levels were not correlated with MDA and HbA1c in NTDs mothers (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>= 0.0006<jats:italic>p<\/jats:italic>= 0.8691 and<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>= 0.001<jats:italic>p<\/jats:italic>= 0.8172, respectively). The conclusion is that AGEs might be associated with NTDs occurrence.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2013.12.002","type":"journal-article","created":{"date-parts":[[2013,12,15]],"date-time":"2013-12-15T12:31:38Z","timestamp":1387110698000},"page":"57-61","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Maternal serum AGEs levels in pregnancies associated with neural tube defects"],"prefix":"10.1002","volume":"33","author":[{"given":"Rulin","family":"Li","sequence":"first","affiliation":[{"name":"Laboratory for Development College of Life Sciences Northwest University Taibai west road 229# Shaanxi Xi'an 710068 People's Republic of China"},{"name":"National Engineering Research Center for Miniaturized Detection System Northwest University Shaanxi Xi'an 710069 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyao","family":"Yang","sequence":"additional","affiliation":[{"name":"Laboratory for Development College of Life Sciences Northwest University Taibai west road 229# Shaanxi Xi'an 710068 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyang","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical sciences Chongqing Medical University Chongqing 401331 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Panyu central Hospital Guang Zhou 511400 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,12,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)91306-F"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1542\/peds.85.1.1","article-title":"Diabetes mellitus during pregnancy and the risks for the specific birth defects: a population\u2010based case\u2010control study","volume":"85","author":"Becerra J.E.","year":"1990","journal-title":"Pediatrics"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.1.105"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.24.8439"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI108436"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg286"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.25.13915"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.2.93"},{"key":"e_1_2_7_10_1","unstructured":"Ejdesj\u00f6A..Teratogenic predisposition in diabetic rat pregnancy.Digital comprehensive summaries of uppsala dissertations from the faculty of medicine 797 Gilbert\u2010Barness E 2010. 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