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Stem cell therapy has been demonstrated as a potential novel therapy for neurological disorders. Compared with other types of stem cells, umbilical cord blood mesenchymal stem cells (UCB\u2010MSCs) have several unique characteristics, such as a higher rate of cell proliferation and clonality. However, the limited life span of UCB\u2010MSCs hinders their clinical application. Therefore, efforts are urgently needed to circumvent this disadvantage. Telomerase reverse transcriptase (TERT), which promotes cell proliferation and survival, plays a protective role in hypoxic\u2010ischemic (HI) brain injury. Thus, it is reasonable to propose that UCB\u2010MSCs modified by exogenous TERT expression might have a longer lifespan and increased viability. 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