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In the present study, we developed stable inducible cell lines (PC12Tet\u2010On\u2010Ataxin\u20103\u2010Q28\/84) expressing ataxin\u20103 with either normal or abnormal CAG repeats under doxycycline control. The expression of acetyl histone H3 and the induction of c\u2010Fos in response to cAMP were strongly suppressed in cells expressing the protein with the expanded polyglutamine tract. Treatment with valproic acid, a histone deacetylase inhibitor (HDACi), attenuated mutant ataxin\u20103\u2010induced cell toxicity and suppression of acetyl histone H3, phosphorylated cAMP\u2010responsive element binding protein (p\u2010CREB) as well as c\u2010Fos expression. These results indicate that VPA can stimulate the up\u2010regulation of gene transcription through hyperacetylation. Thus, VPA might have a therapeutic effect on MJD.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2014.07.004","type":"journal-article","created":{"date-parts":[[2014,7,25]],"date-time":"2014-07-25T15:27:30Z","timestamp":1406302050000},"page":"17-22","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Valproic acid attenuates the suppression of acetyl histone H3 and CREB activity in an inducible cell model of Machado\u2013Joseph disease"],"prefix":"10.1002","volume":"38","author":[{"given":"X.P.","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Huiqiao Building Nanfang Hospital Southern Medical University Guangzhou Guangdong Province China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Neurological Intensive Care Unit First Affiliated Hospital Sun Yat\u2010sen University Guangzhou Guangdong Province 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