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Neurological morbidities in IUGR infants are correlated with changes hippocampal volume. We previously demonstrated that IUGR alters hippocampal cellular composition in both neonatal and juvenile rat pups in association with altered hippocampal gene expression and epigenetic determinants. PPAR\u03b3 signaling is important for neurodevelopment as well as epigenetic integrity in the brain via the PPAR\u03b3\u2010Setd8\u2010H4K20me<jats:sup>1<\/jats:sup> axis and Wnt signaling. We hypothesized that IUGR would decrease expression of PPAR\u03b3, Setd8, and H4K20me<jats:sup>1<\/jats:sup> in juvenile rat hippocampus. We further hypothesized that reduced PPAR\u03b3\u2010Setd8\u2010H4K20me<jats:sup>1<\/jats:sup> would be associated with reduced Wnt signaling genes Wnt3a and \u03b2\u2010catenin, and wnt target gene Axin2. To test our hypothesis we used a rat model of uteroplacental insufficiency\u2010induced IUGR. We demonstrated that PPAR\u03b3 localizes to oligodendrocytes, neurons and astrocytes within the juvenile rat hippocampus. We also demonstrated that IUGR reduces levels of PPAR\u03b3, Setd8 and H4K20me<jats:sup>1<\/jats:sup> in male and female juvenile rat hippocampus in conjunction with reduced Wnt signaling components in only male rats. We speculate that reduced PPAR\u03b3 and Wnt signaling may contribute to altered hippocampal cellular composition which, in turn, may contribute to impaired neurodevelopment and subsequent neurocognitive impairment in IUGR offspring.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2014.07.008","type":"journal-article","created":{"date-parts":[[2014,8,11]],"date-time":"2014-08-11T14:00:49Z","timestamp":1407765649000},"page":"59-67","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["IUGR disrupts the PPAR\u03b3\u2010Setd8\u2010H4K20me<sup>1<\/sup> and Wnt signaling pathways in the juvenile rat hippocampus"],"prefix":"10.1002","volume":"38","author":[{"given":"Xingrao","family":"Ke","sequence":"first","affiliation":[{"name":"Department of Pediatrics Medical College of Wisconsin Milwaukee WI 53226 United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bohan","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Utah Salt Lake City UT 84158 United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baifeng","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Utah Salt Lake City UT 84158 United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Utah Salt Lake City UT 84158 United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amber","family":"Majnik","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Medical College of Wisconsin Milwaukee WI 53226 United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Medical College of Wisconsin Milwaukee WI 53226 United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Lane","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Medical College of Wisconsin Milwaukee WI 53226 United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Joss\u2010Moore","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Utah Salt Lake City UT 84158 United States"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,8,11]]},"reference":[{"issue":"2","key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1016\/j.neuroimage.2012.01.059","article-title":"Altered small\u2010world topology of structural brain networks in infants with intrauterine growth restriction and its association with later neurodevelopmental outcome","volume":"60","author":"Batalle D.","year":"2012","journal-title":"Neuroimage"},{"issue":"3","key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1046\/j.1471-4159.2002.00990.x","article-title":"Protective action of the peroxisome proliferator\u2010activated receptor\u2010gamma agonist pioglitazone in a mouse model of Parkinson's disease","volume":"82","author":"Breidert T.","year":"2002","journal-title":"J. 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