{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:26:19Z","timestamp":1790709979350,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,11,26]],"date-time":"2014-11-26T00:00:00Z","timestamp":1416960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Oxidative stress increases serum thioredoxin (TRX), a redox\u2010regulating protein with antioxidant activity recognized as an oxidative\u2010stress marker. The aim of this study was to assess the clinical significance of serum TRX levels in Autism spectrum disorders (ASD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty patients diagnosed with ASD and 100 sex and age matched typically developing children were assessed for serum TRX content at admission. TRX were assayed with solid\u2010phase sandwich ELISA, and severity of ASD was evaluated with the Childhood Autism Rating Scale (CARS) Score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results indicated that the median serum TRX levels were significantly (<jats:italic>P<\/jats:italic> &lt; 0.0001) higher in children with ASD as compared to typically developing children [17.9(IQR: 10.7\u201325.8) ng\/ml and 5.5(3.6\u20139.2) ng\/ml, respectively]. Levels of TRX increased with increasing severity of ASD as defined by the CARS score. After adjusting for all other possible covariates, TRX still was an independent diagnosis marker of ASD with an adjusted OR of 1.454 (95% CI, 1.232\u20131.892; <jats:italic>P<\/jats:italic> &lt; 0.0001). Based on the receiver operating characteristic (ROC) curve, the optimal cut\u2010off value of serum TRX levels as an indicator for auxiliary diagnosis of autism was projected to be 10.6 ng\/ml. Further, we found that an increased diagnosis of ASD was associated with TRX levels \u226510.6 ng\/ml (adjusted OR 15.31, 95% CI: 7.36\u201331.85) after adjusting for possible confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study demonstrated that serum TRX levels were associated with ASD, and elevated levels could be considered as a novel, independent diagnosis indicator of ASD.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijdevneu.2014.11.007","type":"journal-article","created":{"date-parts":[[2014,11,26]],"date-time":"2014-11-26T21:27:52Z","timestamp":1417037272000},"page":"92-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Thioredoxin: A novel, independent diagnosis marker in children with autism"],"prefix":"10.1002","volume":"40","author":[{"given":"Qing\u2010biao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pediatric Internal Medicine Linyi People's Hospital Linyi Shandong Province PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si\u2010ju","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Pediatric Internal Medicine Linyi People's Hospital Linyi Shandong Province PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010xiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pediatric Internal Medicine Linyi People's Hospital Linyi Shandong Province PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,26]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1476-5381.2011.01336.x","article-title":"Thioredoxin interacting protein is a novel mediator of retinal inflammation and neurotoxicity","volume":"164","author":"Al\u2010Gayyar M.M.H.","year":"2011","journal-title":"Br. 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