{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T21:51:09Z","timestamp":1759960269203},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,2,19]],"date-time":"2015-02-19T00:00:00Z","timestamp":1424304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004632","name":"Mother and Child Health Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004632","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of this study was to assess the relationship between the cerebral blood volume (CBV) measured by near\u2010infrared time\u2010resolved spectroscopy (TRS) and pathological change of the brain in a hypoxic\u2010ischemic (HI) piglet model.<\/jats:p><jats:p>Twenty\u2010one anesthetized newborn piglets, including three sham controls, were studied. An HI event was induced by low inspired oxygen. CBV was measured using TRS (Hamamatsu TRS\u201010). Data were collected before, during, and 6 h after the insult. CBV was calculated as the change from the end of the insult. The piglets were allowed to recover from anesthesia for 6 h after the insult. At the age of 5 days, the brains of the piglets were perfusion\u2010fixed, and histologic evaluations of brain tissue were performed. The extent of histopathological damage was graded in 0.5\u2010unit intervals on a 9\u2010step scale.<\/jats:p><jats:p>CBV increments were well correlated with histopathological scores, especially at 1 and 3 h after resuscitation. Spearman's rank\u2010correlation coefficients at 1, 3, and 6 h after resuscitation in the gray matter were 0.9016, 0.9127, and 0.6907, respectively.<\/jats:p><jats:p>We conclude that an increased CBV after HI insult indicates more marked histological brain damage. CBV measurement immediately after resuscitation provides a more precise prediction of the histological outcome.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2015.02.009","type":"journal-article","created":{"date-parts":[[2015,2,19]],"date-time":"2015-02-19T19:53:34Z","timestamp":1424375614000},"page":"1-9","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Cerebral blood volume measurement using near\u2010infrared time\u2010resolved spectroscopy and histopathological evaluation after hypoxic\u2010ischemic insult in newborn piglets"],"prefix":"10.1002","volume":"42","author":[{"given":"Makoto","family":"Nakamura","sequence":"first","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Kagawa University Kagawa Japan"},{"name":"Department of Neonatology National Hospital Organization Okayama Medical Center Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Jinnai","sequence":"additional","affiliation":[{"name":"Maternal Perinatal Center Faculty of Medicine Kagawa University Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Hamano","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Kagawa University Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Kagawa University Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kosuke","family":"Koyano","sequence":"additional","affiliation":[{"name":"Maternal Perinatal Center Faculty of Medicine Kagawa University Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Chiba","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Host Defense Faculty of Medicine Kagawa University Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Kanenishi","sequence":"additional","affiliation":[{"name":"Maternal Perinatal Center Faculty of Medicine Kagawa University Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saneyuki","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Maternal Perinatal Center Faculty of Medicine Kagawa University Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Ueno","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Host Defense Faculty of Medicine Kagawa University Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanori","family":"Miki","sequence":"additional","affiliation":[{"name":"Departments of Anatomy and Neurobiology Faculty of Medicine Kagawa University Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Hata","sequence":"additional","affiliation":[{"name":"Departments of Perinatology and Gynecology Faculty of Medicine Kagawa University Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kusaka","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Faculty of Medicine Kagawa University Kagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,2,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410240208"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2011.09.008"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","unstructured":"D.V.Azzopardi B.Strohm A.D.Edwards L.Dyet H.L.Halliday E.Juszczak O.Kapellou M.Levene N.Marlow E.Porter M.Thoresen A.Whitelaw P.Brocklehurst.Moderate Hypothermia to Treat Perinatal Asphyxial Encephalopathy.N. 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