{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T21:39:31Z","timestamp":1792186771501,"version":"4.4.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,4,8]],"date-time":"2015-04-08T00:00:00Z","timestamp":1428451200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2015,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although prenatal undernutrition affects the development of metabolic, physiological, and reproductive functions, it remains unclear whether it also affects physiological responses to undernutrition in adulthood. Therefore, in this study we examined whether prenatal undernutrition alters the sensitivity of the hypothalamic\u2013pituitary\u2013gonadal (HPG) axis to fasting in adult male rats. The offspring of <jats:italic>ad libitum<\/jats:italic> fed dams (control) and \u223c50% food\u2010restricted (during the late gestational period) dams (IUGR) were sub\u2010divided into <jats:italic>ad libitum<\/jats:italic> fed (fed) and 48 h food deprivation (FD) groups at 10 weeks of age. In each group, the serum levels of luteinizing hormone (LH), testosterone, and leptin and the hypothalamic mRNA expression levels of gonadotropin\u2010releasing hormone (GnRH) regulatory factors were measured. The serum LH and testosterone levels of the IUGR\u2010fed rats were significantly or tend to be higher than those of the control\u2010fed rats, respectively. The serum LH levels of the IUGR\u2010FD rats were lower than those of the IUGR\u2010fed rats. Similarly, the serum testosterone levels of the IUGR\u2010FD rats tended to be lower than those of the IUGR\u2010fed rats. On the other hand, the serum LH and testosterone levels of the control\u2010fed and control\u2010FD rats did not differ. The serum leptin levels of the IUGR fed rats were higher than those of the control\u2010fed rats. The serum leptin levels of the control\u2010FD and IUGR\u2010FD rats were lower than those of the control\u2010fed and IUGR\u2010fed rats, respectively. The hypothalamic neuropeptide Y (NPY) mRNA levels of the IUGR\u2010FD rats were higher than those of the IUGR\u2010fed rats. Similarly, hypothalamic NPY mRNA levels of control\u2010FD rats were higher than those of the control\u2010fed rats. The hypothalamic kisspeptin, kisspeptin receptor, RFamide\u2010related peptide, GPR147, and OBRb mRNA levels of control fed rats did not differ between control\u2010fed and IUGR\u2010fed rats. Their mRNA levels of the fed and FD rats did not differ in the control or IUGR groups. These results suggested that prenatal undernutrition increased the basal LH and testosterone production, whereas they are easily reduced by food deprivation in male rats. Changes of serum leptin level, but not of hypothalamic reproductive related factors, might be involved in these alterations. However, the precise mechanisms responsible for these effects remain unclear.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2015.04.001","type":"journal-article","created":{"date-parts":[[2015,4,11]],"date-time":"2015-04-11T02:24:13Z","timestamp":1428719053000},"page":"66-69","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["LH and testosterone production are more sensitive to the suppressive effects of food deprivation in prenatally undernourished male rats"],"prefix":"10.1002","volume":"43","author":[{"given":"Takeshi","family":"Iwasa","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology The University of Tokushima Graduate School Institute of Health Biosciences 3\u201018\u201015 Kuramoto\u2010Cho Tokushima 770\u20108503 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiya","family":"Matsuzaki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The University of Tokushima Graduate School Institute of Health Biosciences 3\u201018\u201015 Kuramoto\u2010Cho Tokushima 770\u20108503 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Altankhuu","family":"Tungalagsuvd","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The University of Tokushima Graduate School Institute of Health Biosciences 3\u201018\u201015 Kuramoto\u2010Cho Tokushima 770\u20108503 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munkhsaikhan","family":"Munkhzaya","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The University of Tokushima Graduate School Institute of Health Biosciences 3\u201018\u201015 Kuramoto\u2010Cho Tokushima 770\u20108503 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Kuwahara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The University of Tokushima Graduate School Institute of Health Biosciences 3\u201018\u201015 Kuramoto\u2010Cho Tokushima 770\u20108503 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Yasui","sequence":"additional","affiliation":[{"name":"Department of Reproductive Technology Institute of Health Biosciences The University of Tokushima Graduate School Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Irahara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology The University of Tokushima Graduate School Institute of Health Biosciences 3\u201018\u201015 Kuramoto\u2010Cho Tokushima 770\u20108503 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,8]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1210409"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0337"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-1415"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2014.02.005"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-13-0509"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1095292"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/71.5.1344s"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.183558"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2014.03.007"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2014.02.001"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2014.03.011"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2014.06.007"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2014.10.002"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-125-1-186"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2013.01.014"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2005.05.005"}],"container-title":["International Journal of Developmental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736574815000490?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736574815000490?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijdevneu.2015.04.001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2015.04.001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.ijdevneu.2015.04.001","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2015.04.001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T23:53:09Z","timestamp":1693957989000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.ijdevneu.2015.04.001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,8]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,6]]}},"alternative-id":["10.1016\/j.ijdevneu.2015.04.001"],"URL":"https:\/\/doi.org\/10.1016\/j.ijdevneu.2015.04.001","archive":["Portico"],"relation":{},"ISSN":["0736-5748","1873-474X"],"issn-type":[{"value":"0736-5748","type":"print"},{"value":"1873-474X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,8]]},"assertion":[{"value":"2015-03-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}