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We observed the serum levels of PUFAs and the expression of related liver metabolic enzymes, including \u03945\u2010desaturase, \u03946\u2010desaturase and elongase (Elovl2), in VPA\u2010exposed and control rats on postnatal day 35 (PND35) and conducted sex dimorphic analysis. We found that the levels of serum PUFAs and related liver metabolic enzymes in the VPA rats were significantly reduced, in association with autism\u2010like behavioral changes, the abnormal expression of apoptosis\u2010related proteins and hippocampal neuronal injury, compared to the control rats and showed sex difference in VPA group. This finding indicated that rats exposed to VPA at the embryonic stage may exhibit reduced synthesis of serum PUFAs due to the down\u2010regulation of liver metabolic enzymes, thereby inducing nervous system injury and behavioral changes, which is affected by sex in the meantime.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2015.04.350","type":"journal-article","created":{"date-parts":[[2015,4,26]],"date-time":"2015-04-26T01:04:48Z","timestamp":1430010288000},"page":"14-21","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Study of the serum levels of polyunsaturated fatty acids and the expression of related liver metabolic enzymes in a rat valproate\u2010induced autism model"],"prefix":"10.1002","volume":"44","author":[{"given":"Gang","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Children's and Adolescent Health Public Health College of Harbin Medical University Harbin 150081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingquan","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Nursing Daqing Campus of Harbin Medical University Daqing 163319 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Children's and Adolescent Health Public Health College of Harbin Medical University Harbin 150081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuelai","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Children's and Adolescent Health Public Health College of Harbin Medical University Harbin 150081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Children's and Adolescent Health Public Health College of Harbin Medical University Harbin 150081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Children's and Adolescent Health Public Health College of Harbin Medical University Harbin 150081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqiu","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Pediatric Second Affiliated Hospital of Harbin Medical University Harbin 150081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Children's and Adolescent Health Public Health College of Harbin Medical University Harbin 150081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonggang","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Daqing Campus of Harbin Medical University Daqing 163319 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijie","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Children's and Adolescent Health Public Health College of Harbin Medical University Harbin 150081 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,4,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2013.03.009"},{"key":"e_1_2_6_3_1","unstructured":"A.P. 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