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Several studies have suggested that the etiology of ASD can be partly explained by oxidative stress. However, the implications of abnormal transsulfuration metabolism and oxidative stress, and their relation with ASD are still unclear. The purpose of this study was to evaluate several transsulfuration pathway metabolites in Chinese participants diagnosed with ASD, to better understand their role in the etiology of this disorder. Fifty children (39 male, 11 female) diagnosed with ASD and 50 age\u2010 and gender\u2010matched non\u2010ASD children (i.e., control group) were included in this study. This prospective blinded study was undertaken to assess transsulfuration and oxidative metabolites, including levels of homocysteine (Hcy), cysteine (Cys), total glutathione (tGSH), reduced glutathione (GSH), oxidized glutathione (GSSG), and glutathione ratio (GSH\/GSSG). The clinical severity of ASD was evaluated with the Childhood Autism Rating Scale (CARS), and the autistic children's present behavior was measured by the Autism Behavior Checklist (ABC). The results indicated that Hcy and GSSG levels were significantly higher in children diagnosed with ASD, Cys, tGSH and GSH levels as well as the GSH\/GSSG ratio showed remarkably lower values in ASD children compared to control subjects. Hcy levels correlated significantly with increasing CARS scores and GSSG levels in children with ASD. Our results suggest that an abnormal transsulfuration metabolism and reduced antioxidant capacity (i.e., hyperhomocysteinemia and increased oxidative stress), and Hcy level appears to have a potentially negative impact on clinical severity of autistic disorder.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2015.06.006","type":"journal-article","created":{"date-parts":[[2015,7,5]],"date-time":"2015-07-05T11:36:45Z","timestamp":1436096205000},"page":"27-32","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Abnormal transsulfuration metabolism and reduced antioxidant capacity in Chinese children with autism spectrum disorders"],"prefix":"10.1002","volume":"46","author":[{"given":"Yu","family":"Han","sequence":"first","affiliation":[{"name":"School of Public Health Tianjin Medical University Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian\u2010qian","family":"Xi","sequence":"additional","affiliation":[{"name":"School of Public Health Tianjin Medical University Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Dai","sequence":"additional","affiliation":[{"name":"School of Public Health Tianjin Medical University Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu\u2010han","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Public Health Tianjin Medical University Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Public Health Tianjin Medical University Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010yuan","family":"Su","sequence":"additional","affiliation":[{"name":"School of Public Health Tianjin Medical University Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Public Health Tianjin Medical University Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,7,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2013.09.010"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-2989"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.18388\/abp.2004_3580"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532-5415.2002.50614.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2008.01.017"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/2040-2392-5-10","article-title":"Protein signatures of oxidative stress response in a patient specific cell line model for autism","volume":"5","author":"Chiocchetti A.G.","year":"2014","journal-title":"Mol. 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