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Alterations in 5\u2010HT levels during the early period of life may signal to feeding behavior and hypothalamic genic expression changes in adulthood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Investigate the effects of hypercaloric diet in adult rats submitted to neonatal serotonin reuptake inhibition on food intake, fat pad mass, plasmatic triglycerides\/cholesterol and gene expression of hypothalamic peptides (POMC, NPY) and serotonin receptors (5\u2010HT<jats:sub>1B<\/jats:sub>, 5\u2010HT<jats:sub>2C<\/jats:sub>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In each litter, 8 pups were divided into two groups: control (C) and fluoxetine (F). From the 1<jats:sup>st<\/jats:sup> to the 21<jats:sup>st<\/jats:sup> postnatal day, C pups received sterile saline while F pups received fluoxetine (10 mg\/kg). From 180 to 215 days, a group of rats from C and F groups were fed hypercaloric diet (CH and FH, 421.4 Kcal\/100 g) while the rest of animals from C and F groups fed chow diet (CC and FC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The use of hypercaloric diet was associated with lower accumulation of white adipose tissue in adult rats subjected to neonatal serotonin reuptake inhibition. Adult rats of group FC showed decreased 5\u2010HT<jats:sub>2C<\/jats:sub> and neuropeptide Y mRNA expression compared with control chow diet group (CC). After chronic use of a hypercaloric diet, the expression of 5\u2010HT<jats:sub>2C<\/jats:sub> was higher in the FH group than the FC group and neuropeptide Y expression decreased in FH related to FC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest that neonatal serotonin reuptake inhibition is associated with better adaptation to hypercaloric diet in adult rats.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijdevneu.2015.07.004","type":"journal-article","created":{"date-parts":[[2015,8,8]],"date-time":"2015-08-08T22:17:49Z","timestamp":1439072269000},"page":"76-81","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Neonatal serotonin reuptake inhibition reduces hypercaloric diet effects on fat mass and hypothalamic gene expression in adult rats"],"prefix":"10.1002","volume":"46","author":[{"given":"L\u00edgia Cristina Monteiro","family":"Galindo","sequence":"first","affiliation":[{"name":"Department of Anatomy Federal University of Pernambuco 50670\u2010901 Recife PE Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuella da Luz Duarte","family":"Barros","sequence":"additional","affiliation":[{"name":"Master Student in Nutrition, Physical Activity and Phenotypic Plasticity, CAV Federal University of Pernambuco 55608\u2010680 Vit\u00f3riaStoAnt\u00e3o Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabeli Lins","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sports Science, CAV Federal University of Pernambuco 55608\u2010680 Vit\u00f3riaStoAnt\u00e3o Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Vinicius de Carvalho","family":"Santana","sequence":"additional","affiliation":[{"name":"Department of Anatomy Federal University of Pernambuco 50670\u2010901 Recife PE Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhowena Jane Barbosa","family":"de Matos","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sports Science, CAV Federal University of Pernambuco 55608\u2010680 Vit\u00f3riaStoAnt\u00e3o Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol G\u00f3is","family":"Leandro","sequence":"additional","affiliation":[{"name":"Department of Physical Education and Sports Science, CAV Federal University of Pernambuco 55608\u2010680 Vit\u00f3riaStoAnt\u00e3o Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra Lopes","family":"de Souza","sequence":"additional","affiliation":[{"name":"Department of Anatomy Federal University of Pernambuco 50670\u2010901 Recife PE Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raul Manh\u00e3es","family":"de Castro","sequence":"additional","affiliation":[{"name":"Department of Nutrition Federal University of Pernambuco 50670\u2010901 Recife Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,8]]},"reference":[{"issue":"3","key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.neuroscience.2010.09.046","article-title":"Dopamine D1 receptor gene expression decreases in the nucleus accumbens upon long\u2010term exposure to palatable food and differs depending on diet\u2010induced obesity phenotype in rats","volume":"171","author":"Alsio J.","year":"2010","journal-title":"Neuroscience"},{"issue":"5","key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0361-9230(01)00614-1","article-title":"Modern views on an ancient chemical: serotonin effects on cell proliferation, maturation, and apoptosis","volume":"56","author":"Azmitia E.C.","year":"2001","journal-title":"Brain Res. 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