{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T20:49:20Z","timestamp":1784580560449,"version":"3.55.0"},"reference-count":50,"publisher":"Wiley","issue":"Part_B","license":[{"start":{"date-parts":[[2015,9,28]],"date-time":"2015-09-28T00:00:00Z","timestamp":1443398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pyrrolizidine alkaloids (PAs) are toxins that are exclusively biosynthesized by plants and are commonly present in foods and herbs. PAs are usually associated with poisoning events in livestock and human beings. The aim of the present study was to evaluate the behavioral and neurochemical effects of prenatal exposure to PA integerrimine N\u2010oxide of rats in adulthood. Pregnant Wistar rats received integerrimine N\u2010oxide from the butanolic residue of <jats:italic>Senecio brasiliensis<\/jats:italic> by gavage on gestational days 6\u201320 at doses of 3, 6 and 9 mg\/kg. During adulthood of the offspring, the following behavioral tests were performed: open\u2010field, plus\u2010maze, forced swimming, catalepsy and stereotypy. Histological analyses and monoamine levels were measured. Male offspring from dams that were exposed to 9 mg\/kg showed an increase in locomotion in the open\u2010field test, an increased frequency of entries and time spent in open arms in elevated plus\u2010maze test, as well as decreased swimming time. In the female offspring from dams that were exposed to 9 mg\/kg, there was an increased time of climbing in forced swimming and intensity of stereotyped behavior. The histological study indicates an increase in the number of multinucleated cells in the liver (6 and 9 mg\/kg). In neurotransmitter analysis, specifically in the striatum, we observed change in dopamine and serotonin levels in the middle dose. Thus, our results indicate that prenatal exposure to integerrimine N\u2010oxide changed behavior in adulthood and neurotransmitter levels in the striatum. Our results agree with previous studies, which showed that integerrimine N\u2010oxide impaired physical and neurobehavioral development in childhood that can persist until adulthood.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2015.09.003","type":"journal-article","created":{"date-parts":[[2015,9,29]],"date-time":"2015-09-29T22:08:01Z","timestamp":1443564481000},"page":"157-164","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prenatal exposure to integerrimine N\u2010oxide enriched butanolic residue from <i>Senecio brasiliensis<\/i> affects behavior and striatal neurotransmitter levels of rats in adulthood"],"prefix":"10.1002","volume":"47","author":[{"given":"Tha\u00edsa M.","family":"Sandini","sequence":"first","affiliation":[{"name":"Department of Clinical and Toxicological Analyses Faculty of Pharmaceutical Sciences University of S\u00e3o Paulo Av. Prof. Dr. Lineu Prestes, 580 05508\u2010000 S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana S.B.","family":"Udo","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analyses Faculty of Pharmaceutical Sciences University of S\u00e3o Paulo Av. Prof. Dr. Lineu Prestes, 580 05508\u2010000 S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago M.","family":"Reis\u2010Silva","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Institute of Psychology University of S\u00e3o Paulo Av. Prof. Dr. Melo de Morais, 1721 05508\u2010030 S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Sanches","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Veterinary Medicine University of Sao Paulo Av. Prof. Dr. Orlando Marques de Paiva, 87 05508 270 S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Martha","family":"Bernardi","sequence":"additional","affiliation":[{"name":"Graduate Program of Environmental and Experimental Pathology and Graduate Program Dentistry Paulista University, UNIP Rua Dr. Bacelar, 1212 04026\u2010002 S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Camilo","family":"Fl\u00f3rio","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Veterinary Medicine University of Sao Paulo Av. Prof. Dr. Orlando Marques de Paiva, 87 05508 270 S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helenice de S.","family":"Spinosa","sequence":"additional","affiliation":[{"name":"Department of Pathology School of Veterinary Medicine University of Sao Paulo Av. Prof. Dr. Orlando Marques de Paiva, 87 05508 270 S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12159"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000243085"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","unstructured":"A.Can D.T.Dao M.Arad C.E.Terrillion S.C.Piantadosi T.D.Gould.The mouse forced swim test.J. Vis. Exp.2012 3638","DOI":"10.3791\/3638-v"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2007.07.036"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(03)00149-5"},{"key":"e_1_2_7_7_1","first-page":"252","article-title":"Hepatic veno\u2010occlusive disease associated with toxicity of pyrrolizidine alkaloids in herbal preparations","volume":"68","author":"Chen Z.","year":"2010","journal-title":"Neth. J. Med."},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf403647u"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2005.03.008"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnins.2013.00036","article-title":"Serotonin and the regulation of mammalian energy balance","volume":"7","author":"Donovan M.H.","year":"2013","journal-title":"Front. Neurosci."},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2011.06.032"},{"key":"e_1_2_7_12_1","unstructured":"European Medicines Agency 2012.Public statement on the use of herbal medicinal products 5 containing toxic unsaturated pyrrolizidine alkaloids (PAs). 2012 1\u201320 http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Public_statement\/2012\/10\/WC500134311.pdf."},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(96)00008-1"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(99)00174-6"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00499.2010"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1081\/DMR-120028426"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2008.05.004"},{"key":"e_1_2_7_18_1","article-title":"The role of the serotonergic system in locomotor recovery after spinal cord injury","volume":"8","author":"Ghosh M.","year":"2015","journal-title":"Front. Neural Circ."},{"key":"e_1_2_7_19_1","first-page":"439","article-title":"Effects of integerrimine on the implantation and intrauterine development of mice","volume":"9","author":"Gimmeler M.C.","year":"1986","journal-title":"Rev. Bras. Genet."},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2013.06.238"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1990.tb16911.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/16.11.2691"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(99)80320-1"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-5748(99)00085-4"},{"key":"e_1_2_7_25_1","first-page":"447","article-title":"Poisoning by pyrrolizidine alkaloids in ruminants and horses in Brazil","volume":"30","author":"Lucena R.B.","year":"2010","journal-title":"Pesq. Vet. Bras."},{"key":"e_1_2_7_26_1","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2223\/JPED.518","article-title":"Hepatic veno\u2010occlusive disease: report of a case","volume":"73","author":"Magnabosco E.M.","year":"1997","journal-title":"J. Pediatric."},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(99)00149-X"},{"key":"e_1_2_7_28_1","first-page":"625","volume-title":"Progress in Brain Research","author":"Monti J.M.","year":"2008"},{"key":"e_1_2_7_29_1","first-page":"387","article-title":"Antimitotic action of integerrimine in rats","volume":"3","author":"Nardi N.B.","year":"1980","journal-title":"Braz. J. Genet."},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9384(97)00462-9"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03200814"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2005.07.004"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(85)90031-7"},{"key":"e_1_2_7_34_1","first-page":"1505","article-title":"Characterization of hepatic DNA damage induced in rats by the pyrrolizidine alkaloid monocrotaline","volume":"44","author":"Petry T.W.","year":"1984","journal-title":"Cancer Res."},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/266730a0"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5742(99)00010-1"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(03)01272-X"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.102.5.748"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2014.05.007"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1383-5718(02)00008-6"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(76)90119-9"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2012.044"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(01)00013-8"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.08.010"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1176\/jnp.5.1.9"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2006.11.004"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2004.08.017"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-010-9191-z"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2007.44"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2005.01.009"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920007781368863"}],"container-title":["International Journal of Developmental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736574815300733?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736574815300733?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijdevneu.2015.09.003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2015.09.003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.ijdevneu.2015.09.003","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2015.09.003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T15:32:18Z","timestamp":1694014338000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.ijdevneu.2015.09.003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9,28]]},"references-count":50,"journal-issue":{"issue":"Part_B","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["10.1016\/j.ijdevneu.2015.09.003"],"URL":"https:\/\/doi.org\/10.1016\/j.ijdevneu.2015.09.003","archive":["Portico"],"relation":{},"ISSN":["0736-5748","1873-474X"],"issn-type":[{"value":"0736-5748","type":"print"},{"value":"1873-474X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,9,28]]},"assertion":[{"value":"2015-07-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-09-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-09-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}