{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:16:32Z","timestamp":1790619392265,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"Part_B","license":[{"start":{"date-parts":[[2015,9,30]],"date-time":"2015-09-30T00:00:00Z","timestamp":1443571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Kir4.1 is the principal K\n                    <jats:sup>+<\/jats:sup>\n                    channel expressed in glial cells. It has been shown that it plays a fundamental role in K\n                    <jats:sup>+<\/jats:sup>\n                    \u2010spatial buffering, an astrocyte\u2010specific process where excess extracellular concentration of K\n                    <jats:sup>+<\/jats:sup>\n                    ions, generated by synaptic activity, is spatially redistributed to distant sites via astrocytic syncytia. Experimental and clinical evidence suggested that abnormality of Kir4.1 function in the brain is involved in different neurological diseases such as epilepsy, dysmyelination, and Huntington's disease. Although it has been shown that Kir4.1 is expressed predominantly in astrocytes in certain areas of the rat brain and its transcript is present in the rat forebrain as early as embryonic day E14, no information is available concerning the temporal sequence of Kir4.1 protein appearance during embryonic and post\u2010natal development.\n                  <\/jats:p>\n                  <jats:p>\n                    Aim of this work was to study the expression pattern of Kir4.1 channel in rat somatosensory cortex and hippocampus during development and to examine its cellular localization with the glial and oligodendroglial markers S100\u2010\u03b2, GFAP, and Olig\u20102. Kir4.1 protein was detected since E20 and a gradual increase of Kir4.1 expression occurred between early postnatal period and adulthood. We showed a gradual shift in Kir4.1 subcellular localization from the soma of astrocytes to distal glial processes. Double immunofluorescence experiments confirmed the cellular localization of Kir4.1 in glial cells. Our data provide the first overview of Kir4.1 developmental expression both in the cortex and hippocampus and support the glial role of Kir4.1 in K\n                    <jats:sup>+<\/jats:sup>\n                    spatial buffering.\n                  <\/jats:p>","DOI":"10.1016\/j.ijdevneu.2015.09.004","type":"journal-article","created":{"date-parts":[[2015,10,2]],"date-time":"2015-10-02T04:24:36Z","timestamp":1443759876000},"page":"198-205","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Developmental expression of Kir4.1 in astrocytes and oligodendrocytes of rat somatosensory cortex and hippocampus"],"prefix":"10.1002","volume":"47","author":[{"given":"Ramona Frida","family":"Moroni","sequence":"first","affiliation":[{"name":"Unit of Clinical Epileptology and Experimental Neurophysiology Fondazione I.R.C.C.S. Istituto Neurologico \u201cC. Besta\u201d Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Inverardi","sequence":"additional","affiliation":[{"name":"Unit of Clinical Epileptology and Experimental Neurophysiology Fondazione I.R.C.C.S. Istituto Neurologico \u201cC. Besta\u201d Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina","family":"Regondi","sequence":"additional","affiliation":[{"name":"Unit of Clinical Epileptology and Experimental Neurophysiology Fondazione I.R.C.C.S. Istituto Neurologico \u201cC. Besta\u201d Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Pennacchio","sequence":"additional","affiliation":[{"name":"Unit of Clinical Epileptology and Experimental Neurophysiology Fondazione I.R.C.C.S. Istituto Neurologico \u201cC. Besta\u201d Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Frassoni","sequence":"additional","affiliation":[{"name":"Unit of Clinical Epileptology and Experimental Neurophysiology Fondazione I.R.C.C.S. Istituto Neurologico \u201cC. Besta\u201d Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,9,30]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1987.sp016361"},{"issue":"4","key":"e_1_2_9_3_1","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/0896-6273(90)90109-S","article-title":"Ion channel expression by white matter glia: the O\u20102A glial progenitor cell","volume":"4","author":"Barres B.A.","year":"1990","journal-title":"Neuron"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2013.01.011"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1997.78.1.461"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2006.tb00289.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22318"},{"issue":"47","key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"15769","DOI":"10.1523\/JNEUROSCI.2078-10.2010","article-title":"Implication of Kir4.1 channel in excess potassium clearance: an in vivo study on anesthetized glial\u2010conditional Kir4.1 knock\u2010out mice","volume":"30","author":"Chever O.","year":"2010","journal-title":"J. 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