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This study was carried out in order to assess the influence of neonatal tactile stimulation (TS) on behavioral and morphological responses related to depression\u2010like and anxiety\u2010like behaviors, assessed following the administration of sertraline (SERT), a selective serotonin re\u2010uptake inhibitor (SSRI). Male pups were submitted to daily TS, from postnatal day 8 (PND8) to postnatal day 14 (PND14), for 10 min every day. On PND50, adult animals were submitted to forced swimming training (15 min). On PND51, half of each experimental group (UH and TS) received a single sub\u2010therapeutic dose of sertraline (SER, 0.3 mg\/kg body weight, i.p.) or its vehicle (C, control group). Thirty minutes after injection, depression\u2010like behaviors were quantified in forced swimming test (FST, for 5 min). On the following day, anxiety\u2010like behaviors were assessed in elevated plus maze (EPM), followed by biochemical assessments. TS per se increased swimming time, decreasing immobility time in FST. Besides, TS per se was able to increase frequency of head dipping and time spent in the open arms of EPM, resulting in decreased anxiety index. In addition, groups exposed to TS showed decreased plasma levels of corticosterone per se. Interestingly, while TS exposure significantly potentiated the antidepressant activity of a subtherapeutic dose of SERT, this drug was able to exacerbate TS\u2010induced anxiolytic activity, as observed in FST and EPM, respectively. Decreased plasma levels of both corticosterone and cortisol in animals exposed to TS and treated with SERT are able to confirm the interesting interaction between this neonatal handling and the antidepressant drug. From our results, we conclude that neonatal TS is able to exert beneficial influence on the ability to cope with stressful situations in adulthood, preventing depression and favorably modulating the action of antidepressant drugs.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2015.09.010","type":"journal-article","created":{"date-parts":[[2015,10,14]],"date-time":"2015-10-14T13:40:40Z","timestamp":1444830040000},"page":"192-197","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Neonatal tactile stimulation decreases depression\u2010like and anxiety\u2010like behaviors and potentiates sertraline action in young rats"],"prefix":"10.1002","volume":"47","author":[{"given":"Daniele","family":"Freitas","sequence":"first","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Bioqu\u00edmica Toxicol\u00f3gica UFSM RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caren T.D.","family":"Antoniazzi","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Farmacologia Universidade Federal de Santa Maria, UFSM RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hecson J.","family":"Segat","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Bioqu\u00edmica Toxicol\u00f3gica UFSM RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vin\u00edcia Garzella","family":"Metz","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia e Farmacologia UFSM RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Taschetto","family":"Vey","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Bioqu\u00edmica Toxicol\u00f3gica UFSM RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel C.S","family":"Barcelos","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Farmacologia Universidade Federal de Santa Maria, UFSM RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago","family":"Duarte","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Farmacologia Universidade Federal de Santa Maria, UFSM RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta M.M.F.","family":"Duarte","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Farmacologia Universidade Federal de Santa Maria, UFSM RS Brazil"},{"name":"Universidade Luterana do Brasil (ULBRA) Santa Maria Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilise Escobar","family":"Burger","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Farmacologia Universidade Federal de Santa Maria, UFSM RS Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Bioqu\u00edmica Toxicol\u00f3gica UFSM RS Brazil"},{"name":"Departamento de Fisiologia e Farmacologia UFSM RS Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,10,9]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2014.07.001"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beproc.2014.01.011"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra073096"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00176837"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.08.002"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/10253890.2012.723075"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.06.018"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2012.05.018"},{"key":"e_1_2_6_10_1","first-page":"331","article-title":"The impact of environment factors in determining post\u2010exposure responses in isogenicstrains of mice: can genetic predisposition explain phenotypic vulnerability","volume":"11","author":"Cohen H.","year":"2007","journal-title":"Int. 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