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Here, we investigated the effects of acute and chronic Hyper\u2010BCAA (H\u2010BCAA) administration on pro\u2010 and anti\u2010inflammatory cytokines in the brains of rats. For acute administration, Wistar rats (10 and 30 days) received three injections of BCAA pool (15.8 \u03bcL\/g at 1\u2010h intervals) or saline, subcutaneously. For chronic administration, Wistar rats (7 days) received of BCAA pool or saline twice a day for 21 days, subcutaneously. Our results showed that acute administration of H\u2010BCAA increased IL\u20101\u03b2 (\u223c78%; <jats:italic>p<\/jats:italic> \u2264 0.009) and TNF\u2010\u03b1 (\u223c155%; <jats:italic>p<\/jats:italic> \u2264 0.026) levels in the cerebral cortex but not in the hippocampus of infant rats. Moreover, IL\u20106 levels were increased in the hippocampus (\u223c135%; <jats:italic>p<\/jats:italic> \u2264 0.009) and cerebral cortex (\u223c417%; <jats:italic>p<\/jats:italic> \u2264 0.008), whereas IL\u201010 levels were decreased only in the hippocampus (\u223c42%; <jats:italic>p<\/jats:italic> \u2264 0.009). However, repeated administration of H\u2010BCAA decreased IL\u20101\u03b2 (\u223c59%; <jats:italic>p<\/jats:italic> \u2264 0.047), IL\u20106 (\u223c70%; <jats:italic>p<\/jats:italic> \u2264 0.009) and IFN\u2010\u03b3 (\u223c70%; <jats:italic>p<\/jats:italic> \u2264 0.008) levels in the cerebral cortex, whereas the IL\u20106 (\u223c67%; <jats:italic>p<\/jats:italic> \u2264 0.009), IL\u201010 (\u223c58%; <jats:italic>p<\/jats:italic> \u2264 0.01) and IFN\u2010\u03b3 (\u223c67%; <jats:italic>p<\/jats:italic> \u2264 0.009) levels were decreased in the hippocampus. These findings suggest that a better understanding of the inflammatory response in MSUD patients may be useful to develop therapeutic strategies to modulate the hyperinflammatory\/hypoinflammatory axis.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2015.11.002","type":"journal-article","created":{"date-parts":[[2015,11,30]],"date-time":"2015-11-30T12:01:01Z","timestamp":1448884861000},"page":"24-30","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Administration of branched\u2010chain amino acids alters the balance between pro\u2010inflammatory and anti\u2010inflammatory cytokines"],"prefix":"10.1002","volume":"48","author":[{"given":"Luciana","family":"Rosa","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Bioenerg\u00e9tica e N\u00facleo de Excel\u00eancia em Neuroci\u00eancias Aplicadas de Santa Catarina (NENASC) Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade Universidade do 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