{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T12:29:48Z","timestamp":1758630588819},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,12,31]],"date-time":"2015-12-31T00:00:00Z","timestamp":1451520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Production and death of deep cerebellar nuclei (DCN) neurons were investigated in the <jats:italic>weaver<\/jats:italic> condition at appropriate anatomical levels throughout the mediolateral (medial, intermediate and lateral) and rostrocaudal (rostral, middle and caudal) axes of three DCN\u2010cell groups: the fastigial, the interposed and the dentate nuclei. Current results have denoted that the deficit of DCN neurons is always more important in the homozygous <jats:italic>weaver<\/jats:italic> than in the heterozygous <jats:italic>weaver<\/jats:italic> mice. No loss of neurons was found in the dentate nucleus. In the mediolateral axis, an intranuclear gradient of depletion was observed in the mutant mice; in a given deep nucleus, neurodegeneration was more prominent in the medial pars than in lateral ones. In the rostrocaudal axis, on the other hand, when each deep nucleus was studied and compared as a whole, neuron loss was higher in the fastigial nucleus than in the interposed nucleus, which, in turn, was more important than in the dentate nucleus. These data suggest that, in the <jats:italic>weaver<\/jats:italic> condition, an internuclear gradient of neurodegeneration exists. Moreover, neurons located in rostral parts of a given nucleus appear to be more vulnerable than those settled in middle parts and these, in turn, are more than the caudal ones. These results seem to indicate the presence of an intranuclear gradient of depletion. Current autoradiographic results have revealed that, in the rostrocaudal axis, deep neurons are settled in the <jats:italic>weaver<\/jats:italic> cerebellum following three neurogenetic gradients. The first of these is internuclear; if each deep nucleus is analyzed and compared as a whole, the fastigial nucleus has more late\u2010generated neurons than the interposed nucleus, and this, in turn, has more than the dentate nucleus. The second gradient is also internuclear; if the proportion of late\u2010born neurons is compared throughout the rostral levels from each deep nucleus, it is observed that proportions increase from the fastigial to the dentate nucleus. A similar picture emerges when the middle and caudal regions are taken into account. The third gradient is intranuclear; in a given deep nucleus, the rostral region always presents more late\u2010produced neurons than the middle region and these, in turn, more than in the caudal level.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2015.12.006","type":"journal-article","created":{"date-parts":[[2015,12,31]],"date-time":"2015-12-31T07:17:00Z","timestamp":1451546220000},"page":"37-45","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Generation and vulnerability of deep cerebellar nuclei neurons in the <i>weaver<\/i> condition along the anteroposterior and mediolateral axes"],"prefix":"10.1002","volume":"49","author":[{"given":"Joaqu\u00edn","family":"Mart\u00ed","sequence":"first","affiliation":[{"name":"Unidad de Citolog\u00eda e Histolog\u00eda, Facultad de Biociencias Universidad Aut\u00f3noma de Barcelona 08193 Bellaterra Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.C.","family":"Santa\u2010Cruz","sequence":"additional","affiliation":[{"name":"Unidad de Citolog\u00eda e Histolog\u00eda, Facultad de Biociencias Universidad Aut\u00f3noma de Barcelona 08193 Bellaterra Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 P.","family":"Herv\u00e1s","sequence":"additional","affiliation":[{"name":"Unidad de Citolog\u00eda e Histolog\u00eda, Facultad de Biociencias Universidad Aut\u00f3noma de Barcelona 08193 Bellaterra Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.05153.x"},{"key":"e_1_2_7_3_1","first-page":"316","article-title":"Differential maturation of GIRK2 expressing neurons in the mouse cerebellum","volume":"92","author":"Aguado C.","year":"2010","journal-title":"Prog. Neurobiol."},{"key":"e_1_2_7_4_1","volume-title":"Structure and Functions","author":"Altman J.","year":"1997"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)90613-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(78)90195-6"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(87)90015-3"},{"issue":"11","key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"6901","DOI":"10.1523\/JNEUROSCI.14-11-06901.1994","article-title":"Correlated quantitative studies of the neostriatum, nucleus accumbens, substantia nigra, and ventral tegmental area in normal and weaver mutant mice","volume":"14","author":"Bayer S.A.","year":"1994","journal-title":"J. Neurosci."},{"key":"e_1_2_7_9_1","first-page":"1041","volume-title":"Neurogenesis and Neuronal Migration. In the Rat Nervous System","author":"Bayer S.A.","year":"1995"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902320110"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.106559"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.02.056"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0861-13.2013"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.16.6032"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00896-2"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19980518)394:4<431::AID-CNE3>3.0.CO;2-2"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/14734220260418420"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(87)90164-3"},{"issue":"3","key":"e_1_2_7_19_1","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/s12311-013-0543-2","article-title":"Cerebellar loops: a review of the nucleocortical pathway","volume":"13","author":"Houck B.D.","year":"2014","journal-title":"Cerebellum"},{"key":"e_1_2_7_20_1","first-page":"126","article-title":"Experimental studies on the intrinsic fibers of the cerebellum II: the corticonuclear projection","volume":"10","author":"Jansen J.","year":"2011","journal-title":"Cerebellum"},{"key":"e_1_2_7_21_1","doi-asserted-by":"crossref","first-page":"36122","DOI":"10.1074\/jbc.M007087200","article-title":"Functional and biochemical evidence for G\u2010protein\u2010gated inwardly rectifying K+ (GIRK) channels composed of GIRK2 and GIRK","volume":"275","author":"Jelacic T.M.","year":"2000","journal-title":"J. Biol. Chem."},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-11-03559.1996"},{"issue":"7","key":"e_1_2_7_23_1","doi-asserted-by":"crossref","first-page":"e70091","DOI":"10.1371\/journal.pone.0070091","article-title":"Development of cerebellar neurons and glias revealed by in utero electroporation:golgi\u2010like labeling of cerebellar neurons and glias","volume":"8","author":"Kita Y.","year":"2013","journal-title":"PLoS One"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.01.031"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(96)01491-6"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(00)00061-7"},{"key":"e_1_2_7_27_1","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1523\/JNEUROSCI.17-10-03675.1997","article-title":"Failed cell migration and death of Purkinje cells and deep nuclear neurons in the weaver cerebellum","volume":"17","author":"Maricich S.M.","year":"1997","journal-title":"J. Neurosci."},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0736-5748(01)00036-3"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.2002.7873"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1385-299X(02)00145-9"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-007-0159-8"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2007.05.002"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-012-0429-8"},{"key":"e_1_2_7_34_1","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2014.00450","article-title":"Cellular commitment in the developing cerebellum","volume":"8","author":"Marzban H.","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1095-126"},{"key":"e_1_2_7_36_1","volume-title":"The Rat Brain in Stereotaxic Coordinates","author":"Patxinos G.","year":"1998"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901520202"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901520203"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(89)90018-9"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(72)90039-5"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(04)82027-5"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbrainres.2005.05.018"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S42019"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2013.06.005"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2013.12.009"},{"key":"e_1_2_7_46_1","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1006\/dbio.1998.9076","article-title":"Girk2 expression in the ventral midbrain, cerebellum, and olfactory bulb and its relationship to the murine mutation weaver","volume":"204","author":"Schein J.C.","year":"1988","journal-title":"Dev. Biol."},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.02-03-00376.1982"},{"key":"e_1_2_7_48_1","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/0006-8993(95)00974-U","article-title":"Morphologial abnormalities in the hippocampus of the weaver mutant mouse","volume":"696","author":"Sekigucchi M.","year":"1995","journal-title":"Brain Res."},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.23.090506.123237"},{"issue":"3","key":"e_1_2_7_50_1","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1080\/14734220701332486","article-title":"The cerebellum: comparative and animal studies","volume":"6","author":"Sultan F.","year":"2007","journal-title":"Cerebellum"},{"key":"e_1_2_7_51_1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s12311-013-0506-7","article-title":"Does the cerebellum initiate movement?","volume":"13","author":"Trach W.T.","year":"2014","journal-title":"Cerebellum"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00248351"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(96)00635-7"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-010-0240-3"},{"key":"e_1_2_7_55_1","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1101\/gr.6.8.678","article-title":"cDNA selection with DNA microdissected from mouse chromosome 16: isolation of novel clones and construction of a partial transcription map of the C3\u2013C4 region","volume":"6","author":"Wei J.","year":"1996","journal-title":"Genome Res."},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1998.5369"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12241"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-15-05608.2000"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00005679"}],"container-title":["International Journal of Developmental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073657481530160X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S073657481530160X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijdevneu.2015.12.006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2015.12.006","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.ijdevneu.2015.12.006","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2015.12.006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:45:02Z","timestamp":1694047502000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.ijdevneu.2015.12.006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,31]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,4]]}},"alternative-id":["10.1016\/j.ijdevneu.2015.12.006"],"URL":"https:\/\/doi.org\/10.1016\/j.ijdevneu.2015.12.006","archive":["Portico"],"relation":{},"ISSN":["0736-5748","1873-474X"],"issn-type":[{"value":"0736-5748","type":"print"},{"value":"1873-474X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,31]]},"assertion":[{"value":"2015-11-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-12-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-12-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}