{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:38:10Z","timestamp":1789141090342,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,5,16]],"date-time":"2016-05-16T00:00:00Z","timestamp":1463356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81371417"],"award-info":[{"award-number":["81371417"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Huntington's disease (HD) is an inherited neurodegenerative disease that is caused by the abnormal expansion of CAG repeats in the gene encoding huntingtin (Htt). Reduced AKT phosphorylation and inhibited AKT activity have been shown to be involved in mutant Htt (mHtt)\u2010induced cell death.\n                    <jats:italic>Lycium barbarum<\/jats:italic>\n                    polysaccharide (LBP), the main bioactive component of\n                    <jats:italic>Lycium barbarum<\/jats:italic>\n                    , reportedly has neuroprotective roles in neural injuries, including neurodegenerative diseases. Here, we report that treatment with LBP can increased the viability of HEK293 cells that stably expressed mHtt containing 160 glutamine repeats and significantly improved motor behavior and life span in HD\u2010transgenic mice. Furthermore, we found that in LBP\u2010treated HEK293 cells expressing mHtt, mHtt levels were reduced and the phosphorylation of AKT at Ser473 (p\u2010AKT\u2010Ser473) was significantly increased. We also found that treatment with LBP increased p\u2010AKT\u2010Ser473 and decreased mHtt in the cortex, hippocampus and striatum in HD\u2010transgenic mice. The level of phosphorylation of p\u2010GSK3\u03b2\u2010Ser9 remained unchanged in both cultured cells and HD\u2010transgenic mice. Our findings suggest that LBP alleviates the cytotoxicity of mHtt by activating AKT and reducing mHtt levels, indicating that LBP may be potentially useful for treating HD.\n                  <\/jats:p>","DOI":"10.1016\/j.ijdevneu.2016.05.004","type":"journal-article","created":{"date-parts":[[2016,5,16]],"date-time":"2016-05-16T14:10:08Z","timestamp":1463407808000},"page":"66-74","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["<i>Lycium barbarum<\/i>\n                    polysaccharide attenuates the cytotoxicity of mutant huntingtin and increases the activity of AKT"],"prefix":"10.1002","volume":"52","author":[{"given":"Fang","family":"Fang","sequence":"first","affiliation":[{"name":"Division of Histology and Embryology Department of Anatomy Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Peng","sequence":"additional","affiliation":[{"name":"Division of Histology and Embryology Department of Anatomy Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 People's Republic of China"},{"name":"Institute for Brain Sciences Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 People's Republic of China"},{"name":"Collaborative Innovation Center for Brain Science Huazhong University of Science and Technology Wuhan 430030 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiming","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Histology and Embryology Department of Anatomy Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixi","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Histology and Embryology Department of Anatomy Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Division of Histology and Embryology Department of Anatomy Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Histology and Embryology Department of Anatomy Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 People's Republic of China"},{"name":"Institute for Brain Sciences Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 People's Republic of China"},{"name":"Collaborative Innovation Center for Brain Science Huazhong University of Science and Technology Wuhan 430030 People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb01045.x"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.292.5521.1552"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-007-9181-x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2008.07.019"},{"key":"e_1_2_6_6_1","article-title":"Lycium barbarum polysaccharides prevent memory and neurogenesis impairments in scopolamine\u2010treated rats","volume":"9","author":"Chen W.W.","year":"2014","journal-title":"PLoS One"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.02.022"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.03985.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(03)01827-2"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0b013e3283550c97"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0084800"},{"key":"e_1_2_6_12_1","article-title":"Activation of the nrf2\/HO\u20101 antioxidant pathway contributes to the protective effects of Lycium barbarum polysaccharides in the rodent retina after ischemia\u2010reperfusion\u2010induced damage","volume":"9","author":"He M.H.","year":"2014","journal-title":"PLoS One"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.04.075"},{"key":"e_1_2_6_14_1","doi-asserted-by":"crossref","first-page":"813","DOI":"10.3233\/JAD-2010-1280","article-title":"Neuroprotective effects of polysaccharides from wolfberry, the fruits of Lycium barbarum, against homocysteine\u2010induced toxicity in rat cortical neurons","volume":"19","author":"Ho Y.S.","year":"2010","journal-title":"J. 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