{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T21:25:29Z","timestamp":1769635529605,"version":"3.49.0"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T00:00:00Z","timestamp":1464220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270414"],"award-info":[{"award-number":["81270414"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neonatal surgery leads to enhanced hyperalgesia to noxious stimulation in adulthood via a mechanism caused by enhanced phosphorylated (p)\u2010p38 expression in microglia. We tested the effect of exercise on reducing enhanced hypersensitivity primed by neonatal incision surgery. Adult female Wistar rats, with or without neonatal incision surgery at postnatal day (P) 3, received right hind paw plantar incision surgery under anesthesia at P44. The rats performed wheel\u2010running exercise from P22 to P41. Paw withdrawal threshold (PWT) and paw withdrawal latency (PWL) were measured and ipsilateral spinal cords were collected for protein quantification. For PWT and PWL, exercise reduced the pain index after incision surgery at P44 in rats with neonatal surgery (P &lt; 0.01). Western blots showed that exercise suppressed P\u2010p38 expression relative to adult rats without neonatal surgery (P &lt; 0.05). Results of ELISA showed that exercise reduced IL\u20101\u03b2 and TNF\u2010\u03b1 (P &lt; 0.05) concentration in the ipsilateral spinal cord. Exercise preconditioning is an effective approach to reducing enhanced adult hyperalgesia primed by neonatal surgery. The mechanism may be explained by exercise\u2010induced inhibition of P\u2010p38 activation and IL\u20101\u03b2, TNF\u2010\u03b1 release.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2016.05.008","type":"journal-article","created":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T04:29:49Z","timestamp":1464323389000},"page":"46-54","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Exercise preconditioning reduces neonatal incision surgery\u2010induced enhanced hyperalgesia via inhibition of P38 mitogen\u2010activated protein kinase and IL\u20101\u03b2, TNF\u2010\u03b1 release"],"prefix":"10.1002","volume":"52","author":[{"given":"Xingrui","family":"Gong","sequence":"first","affiliation":[{"name":"Department of Anesthesiology &amp; Pediatric Clinical Pharmacology Laboratory Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology &amp; Pediatric Clinical Pharmacology Laboratory Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mazhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology &amp; Pediatric Clinical Pharmacology Laboratory Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-1363"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2006.11.016"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"5367","DOI":"10.4049\/jimmunol.162.9.5367","article-title":"The role of p38 mitogen\u2010activated protein kinase in IL\u20101 beta transcription","volume":"162","author":"Baldassare J.J.","year":"1999","journal-title":"J. Immunol."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.72.1.F47"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.07.012"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr288"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.07.075"},{"issue":"2","key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1177\/0394632015593220","article-title":"Safety and efficacy of intra\u2010articular anti\u2010tumor necrosis factor alpha agents compared to corticosteroids in a treat\u2010to\u2010target strategy in patients with inflammatory arthritis and monoarthritis flare","volume":"29","author":"Carubbi F.","year":"2016","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1721727X15588433"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(88)90206-5"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2014.08.030"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2008.12.012"},{"key":"e_1_2_8_14_1","first-page":"787","article-title":"Role of TNF in mast cell neuroinflammation and pain","volume":"29","author":"Gu Y.","year":"2015","journal-title":"J. Biol. Regul. Homeost. A"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.5560031213"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.08.026"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.08.026"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2008.03.004"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.5717\/jenb.2015.15060203"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2008.12.011"},{"key":"e_1_2_8_21_1","first-page":"105","article-title":"Exercise training inhibits inflammation in adipose tissue via both suppression of macrophage infiltration and acceleration of phenotypic switching from M1 to M2 macrophages in high\u2010fat\u2010diet\u2010induced obese mice","volume":"16","author":"Kawanishi N.","year":"2010","journal-title":"Exerc. Immunol. Rev."},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.267518"},{"key":"e_1_2_8_23_1","first-page":"19","article-title":"Schnitzler syndrome responding to interleukin\u20101 antagonist anakinra","volume":"29","author":"Koch A.","year":"2015","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2007.08.001"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.08.010"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/neuro.08.031.2009"},{"key":"e_1_2_8_27_1","doi-asserted-by":"crossref","unstructured":"A.Leung N.S.Gregory L.H.Allen K.A.Sluka.Regular physical activity prevents chronic pain by altering resident muscle macrophage phenotype and increasing IL\u201010 in mice.Pain.2015;1","DOI":"10.1097\/j.pain.0000000000000312"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-011-9257-8"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00627-2"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.0329c.xd"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2005.01.014"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1358\/dnp.2002.15.10.740239"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.218"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12414"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000659"},{"key":"e_1_2_8_36_1","doi-asserted-by":"crossref","unstructured":"M.Soens J.C.F.Wang T.Berta G.Strichartz.Systemic progesterone administration in early life alters the hyperalgesic responses to surgery in the adult.Anesth. Analgesia.2015;1","DOI":"10.1213\/ANE.0000000000000800"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2012.10.003"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022155432262"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.10.5342"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2009.08.017"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000658"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-106-1-306"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1089\/107999000312423"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-6-84"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152411794961040"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1179\/1743132815Y.0000000015"}],"container-title":["International Journal of Developmental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736574816300132?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736574816300132?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijdevneu.2016.05.008","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2016.05.008","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.ijdevneu.2016.05.008","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2016.05.008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T21:18:49Z","timestamp":1694035129000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.ijdevneu.2016.05.008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,26]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1016\/j.ijdevneu.2016.05.008"],"URL":"https:\/\/doi.org\/10.1016\/j.ijdevneu.2016.05.008","archive":["Portico"],"relation":{},"ISSN":["0736-5748","1873-474X"],"issn-type":[{"value":"0736-5748","type":"print"},{"value":"1873-474X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,26]]},"assertion":[{"value":"2016-01-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}