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We examined NSSs in Chinese adolescents with schizophrenia and schizotypal personality traits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty\u2010seven schizophrenic adolescents (SCH group), 85 adolescents with only schizotypal personality traits (SPT group), and 88 healthy controls (HC group) were enrolled. The NSS subscales of the Cambridge Neurological Inventory (CNI) were administered to all 260 participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The NSS prevalence rates were higher in the SCH group than in the other two groups for both hands in the fist\u2010edge\u2010palm, Oseretsky, and graphesthesia tests. Relative to HCs, the SCH group also showed higher NSS prevalence rates in the right finger agnosia and right mirror movement of finger opposition tests. SCH &gt; SPT &gt; HC trends were observed for all NSS subscale scores and for the left, right, and total NSS scores.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To our knowledge, the present study is the first to examine NSSs in adolescents with schizophrenia and adolescents with schizotypal personality traits. These results provide preliminary findings suggesting that schizophrenia spectrum disorders may be characterized by developmental abnormalities in the central nervous system, and support the notion that NSSs may be schizophrenia spectrum disorder biomarkers.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijdevneu.2016.07.002","type":"journal-article","created":{"date-parts":[[2016,7,17]],"date-time":"2016-07-17T10:55:44Z","timestamp":1468752944000},"page":"53-57","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Neurological soft signs in Chinese adolescents with schizophrenia and schizotypal personality traits"],"prefix":"10.1002","volume":"53","author":[{"given":"Xin","family":"Wang","sequence":"first","affiliation":[{"name":"Medical Psychological Center Second Xiangya Hospital Central South University Changsha Hunan 410011 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Cai","sequence":"additional","affiliation":[{"name":"School of Sociology and Psychology Southwest University for Nationalities Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingyan","family":"Li","sequence":"additional","affiliation":[{"name":"Medical Psychological Center Second Xiangya Hospital Central South University Changsha Hunan 410011 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medical Psychology Public Health Institute of Harbin Medical University Harbin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiongzhao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Medical Psychological Center Second Xiangya Hospital Central South University Changsha Hunan 410011 China"},{"name":"Medical Psychological Institute of Central South University Changsha Hunan 410011 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,16]]},"reference":[{"issue":"6","key":"e_1_2_7_2_1","first-page":"1273","article-title":"Mirror movement associated with neural tube defects","volume":"4","author":"Andrabi Y.","year":"2008","journal-title":"Neuropsychiatr. 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