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Thus the increased vulnerability of females towards clinical depression and anxiety\u2010related disorders remains incompletely understood. Development of clinical models of depression in adolescent females is essential in order to evolve effective treatment strategies for adolescent depression. In the present study, we have examined the anxiety and depressive\u2010like profiles in a putative animal model of childhood depression, the Wistar Kyoto (WKY) rat, during early adolescence (\u223cpostnatal day 30) and mid\u2010adolescence (\u223cpostnatal day 40). Female adolescent WKY rats, tested on a series of behavioural tests modelling anxiety\u2010 and depressive\u2010like behaviours with age\u2010matched Wistars as controls, demonstrated marked differences during early adolescence in a strain\u2010 and age\u2010specific manner. Anxiety indices were obtained from exposure to the elevated plus maze, where social communication vide 50\u2010kHz ultrasonic vocalizations was also assessed, while immobility and other parameters in the forced swim test were screened for depressive\u2010like profiles. Sucrose preference, used as a measure of anhedonia in animals, was lower in WKYs at both ages tested and decreased with age. Anxiety\u2010related behaviours were prominent in WKY rats only during early adolescence. WKY female rats are anxious during early adolescence and exhibit anhedonia as a core symptom of depression during early\u2010 and mid\u2010adolescence, thus indicating that inclusion of female animals in preclinical trials is essential and will contribute to gender\u2010based approaches to diagnosis and treatment of adolescent depression in females.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2016.11.003","type":"journal-article","created":{"date-parts":[[2016,11,11]],"date-time":"2016-11-11T18:30:23Z","timestamp":1478889023000},"page":"18-26","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Anxiety\u2010 and depressive\u2010like profiles during early\u2010 and mid\u2010adolescence in the female Wistar Kyoto rat"],"prefix":"10.1002","volume":"56","author":[{"given":"Deepthi","family":"D'Souza","sequence":"first","affiliation":[{"name":"Brain Research Laboratory Biotechnology Unit Department of Biosciences Mangalore 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