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Hence, we determined the concentration of catecholamines and indoleamines at the hypothalamus of 56 swine fetuses obtained at both 70 and 90 days of pregnancy (n = 33 and 23 fetuses, respectively). The degree of fetal development and the fetal sex affected the neurotransmitters profile at both stages. At Day 70, there were found higher mean concentrations of <jats:sc>l<\/jats:sc>\u2010DOPA in both female and male fetuses with severe IUGR; male fetuses with severe IUGR also showed higher concentrations of TRP than normal male littermates. At Day 90 of pregnancy, the differences between sexes were more evident. There were no significant effects from either severe IUGR on the neurotransmitter profile in male fetuses. However, in the females, a lower body\u2010weight was related to lower concentrations of <jats:sc>l<\/jats:sc>\u2010DOPA and TRP and those female fetuses affected by severe IUGR evidenced lower HVA concentration. In conclusion, the fetal synthesis and use of neurotransmitters increase with time of pregnancy but, in case of IUGR, both catecholamines and indoleamines pathways are affected by sex\u2010related effects.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2017.01.005","type":"journal-article","created":{"date-parts":[[2017,1,16]],"date-time":"2017-01-16T15:05:02Z","timestamp":1484579102000},"page":"72-76","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Fetal growth\u2010retardation and brain\u2010sparing by malnutrition are associated to changes in neurotransmitters profile"],"prefix":"10.1002","volume":"57","author":[{"given":"C.","family":"Garc\u00eda\u2010Contreras","sequence":"first","affiliation":[{"name":"INIA Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Valent","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary UAB Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"V\u00e1zquez\u2010G\u00f3mez","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary UCM Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Arroyo","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary UAB Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Isabel","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary UCM Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Astiz","sequence":"additional","affiliation":[{"name":"INIA Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bassols","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary UAB Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Gonzalez\u2010Bulnes","sequence":"additional","affiliation":[{"name":"INIA Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,16]]},"reference":[{"issue":"3","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1469-7793.2000.00519.x","article-title":"Actions of hypoxia on catecholamine synthetic enzyme mRNA expression before and after development of adrenal innervation in the sheep fetus","volume":"529","author":"Adams M.B.","year":"2000","journal-title":"J. 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