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There is also increasing evidence suggesting that activation or blockade of the GABA\u2010A receptors during early life can induce brain and behavioral abnormalities in adulthood. We investigated whether neonatal blockade of the GABA\u2010A receptors by bicuculline can alter anxiety\u2010 and depression\u2010like behaviors, body weight, food intake, corticosterone and testosterone levels in adult mice (postnatal days 80\u201395). To this end, neonatal mice were treated with either DMSO or bicuculline (70, 150 and 300 \u03bcg\/kg) during postnatal days 7, 9 and 11. When grown to adulthood, mice were exposed to behavioral tests to measure anxiety\u2010 (elevated plus\u2010maze and light\u2010dark box) and depression\u2010like behaviors (tail suspension test and forced swim test). Stress\u2010induced serum corticosterone and testosterone levels, body weight and food intake were also evaluated. Neonatal bicuculline exposure at dose of 300 \u03bcg\/kg decreased anxiety\u2010like behavior, stress\u2010induced corticosterone levels and increased testosterone levels, body weight and food intake, without significantly influencing depression\u2010like behavior in adult male mice. However, no significant changes in these parameters were observed in adult females. These findings suggest that neonatal blockade of GABA\u2010A receptors affects anxiety\u2010like behavior, physiological and hormonal parameters in a sex\u2010dependent manner in mice. Taken together, these data corroborate the concept that GABA\u2010A receptors during early life have an important role in programming neurobehavioral phenotypes in adulthood.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2017.01.007","type":"journal-article","created":{"date-parts":[[2017,1,19]],"date-time":"2017-01-19T12:09:52Z","timestamp":1484827792000},"page":"62-71","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Neonatal blockade of GABA\u2010A receptors alters behavioral and physiological phenotypes in adult mice"],"prefix":"10.1002","volume":"57","author":[{"given":"Ali\u2010Akbar","family":"Salari","sequence":"first","affiliation":[{"name":"Drug Applied Research Center, Tabriz University of Medical Sciences Tabriz Iran"},{"name":"Salari Institute of Cognitive and Behavioral Disorders Alborz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Amani","sequence":"additional","affiliation":[{"name":"Department of Physiology, Faculty of Medicine Ardabil University of Medical Sciences Ardabil Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,19]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00341-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/hbeh.2002.1838"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2013.04.056"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2006.1860"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2013.12.003"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901900107"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.136"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(71)90231-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.neuroscience.2014.08.001","article-title":"The GABA excitatory\/inhibitory developmental sequence: a personal journey","volume":"24","author":"Ben\u2010Ari Y.","year":"2014","journal-title":"Neuroscience"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0b013e3283633662"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1006\/hbeh.1993.1041"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001362"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.04.056"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","DOI":"10.1002\/0471142301.ns0810as55","article-title":"Rodent models of depression: forced swim and tail suspension behavioral despair tests in rats and mice","volume":"55","author":"Castagn\u00e9 V.","year":"2011","journal-title":"Curr. 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