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This study aimed to determine the effect of maternal dipyrone treatment during lactation on offspring development and emotional behavior and on the dam's maternal behavior. Hence, on postnatal day (PND) 2, drinking water only or drinking water containing dipyrone at doses of 100, 300, and 500 mg\/kg\/day, were offered to lactating mothers up to PND9. Thereafter, all mice were provided regular drinking water. On PND2, all litters were culled to 8 pups (4 males and 4 females). Maternal behavior was evaluated at PND3, 6, 9, and 12, and at PND7 we evaluated locomotor activity in the open field. Reflex parameters and physical development of offspring were evaluated during lactation. At PND7, analysis of ultrasonic vocalization (USV) was performed. When the animals reached adolescence, we evaluated their performance in the open field, elevated plus maze (EPM), and marble burying. Our data demonstrated that maternal dipyrone treatment during lactation not only altered maternal behavior and the onset of physical and neurodevelopmental landmarks but also had an impact on anxiety\u2010like behavior in offspring.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2017.02.005","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T02:31:02Z","timestamp":1487644262000},"page":"74-81","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Maternal dipyrone treatment during lactation in mice reduces maternal behavior and increases anxiety\u2010like behavior in offspring"],"prefix":"10.1002","volume":"58","author":[{"given":"Vanessa Barbosa","family":"Veronesi","sequence":"first","affiliation":[{"name":"Departamento de Ci\u00eancias Fisiol\u00f3gicas Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal de Alfenas (Unifal\u2010MG) Alfenas Minas Gerais Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Bioci\u00eancias Aplicadas \u00e0 Sa\u00fade Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiane Helena","family":"Batista","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Fisiol\u00f3gicas Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal de Alfenas (Unifal\u2010MG) Alfenas Minas Gerais Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Bioci\u00eancias Aplicadas \u00e0 Sa\u00fade Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Cl\u00e1udia Alves Freire","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Fisiol\u00f3gicas Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal de Alfenas (Unifal\u2010MG) Alfenas Minas Gerais Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Bioci\u00eancias Aplicadas \u00e0 Sa\u00fade Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Giusti\u2010Paiva","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Fisiol\u00f3gicas Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal de Alfenas (Unifal\u2010MG) Alfenas Minas Gerais Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Bioci\u00eancias Aplicadas \u00e0 Sa\u00fade Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabiana Cardoso","family":"Vilela","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias Fisiol\u00f3gicas Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal de Alfenas (Unifal\u2010MG) Alfenas Minas Gerais Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Bioci\u00eancias Aplicadas \u00e0 Sa\u00fade Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,2,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000473"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/bfm.2016.0044"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-200326130-00002"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2004.07.004"},{"key":"e_1_2_7_6_1","first-page":"1","article-title":"Protein malnutrition during pregnancy alters maternal behavior and anxiety\u2010like behavior in offspring","volume":"28","author":"Batista T.H.","year":"2016","journal-title":"Nutr. 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