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Two experimental groups were used: Control Group (CTG) \u2212 offspring of rats injected with saline during pregnancy and Cerebral Palsy Group (CPG) \u2212 offspring of rats injected with lipopolysaccharide during pregnancy, submitted to perinatal asphyxia and sensorimotor restriction for 30 days. At 29 days of age, the CPG exhibited coordination between limbs, weight\u2010supported dorsal steps or weight\u2010supported plantar steps with paw rotation. At 45 days of age, CPG exhibited plantar stepping with the paw rotated in the balance phase. An increase in the number of glial cells in the primary somatosensory cortex and dorsal striatum were observed in the CPG, but the corpus callosum thickness and cross\u2010sectional area of lateral ventricle were similar between studied groups. No changes were found in the number of motoneurons, glial cells and soma area of the motoneurons in the ventral horn of spinal cord. The combination of insults in the pre, peri and postnatal periods produced changes in hindlimbs gait pattern of animals similar to those observed in diplegic patients, but motor impairments were attenuated over time. Besides, the greater number of glial cells observed seems to be related to the formation of a glial scar in important sensorimotor brain areas.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2017.04.005","type":"journal-article","created":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T11:30:35Z","timestamp":1493638235000},"page":"48-55","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Characterization of a cerebral palsy\u2010like model in rats: Analysis of gait pattern and of brain and spinal cord motor areas"],"prefix":"10.1002","volume":"60","author":[{"given":"Adriana Souza","family":"dos Santos","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Morfologia Experimental, Centro de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Universidade Estadual do Oeste do Paran\u00e1, Rua Universit\u00e1ria 1619, Cascavel Paran\u00e1 CEP: 85819\u2010110 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wellington","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Morfologia Experimental, Centro de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Universidade Estadual do Oeste do Paran\u00e1, Rua Universit\u00e1ria 1619, Cascavel Paran\u00e1 CEP: 85819\u2010110 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Popik","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Morfologia Experimental, Centro de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Universidade Estadual do Oeste do Paran\u00e1, Rua Universit\u00e1ria 1619, Cascavel Paran\u00e1 CEP: 85819\u2010110 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno Marques","family":"Sbardelotto","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Morfologia Experimental, Centro de Ci\u00eancias M\u00e9dicas e Farmac\u00eauticas, Universidade Estadual do Oeste do Paran\u00e1, Rua Universit\u00e1ria 1619, Cascavel Paran\u00e1 CEP: 85819\u2010110 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia Miranda","family":"Torrejais","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Morfologia Experimental, Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Bioci\u00eancias e Sa\u00fade, Universidade Estadual do Oeste do Paran\u00e1, Rua Universit\u00e1ria 1619, Cascavel Paran\u00e1 CEP: 85819\u2010110 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Alves","family":"de Souza","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1, Rua General Rondon 2195, Toledo Paran\u00e1 CEP: 85902\u2010090 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edgia Aline","family":"Centenaro","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Morfologia Experimental, Centro de Ci\u00eancias M\u00e9dicas e Farmac\u00eauticas, Universidade Estadual do Oeste do Paran\u00e1, Rua Universit\u00e1ria 1619, Cascavel Paran\u00e1 CEP: 85819\u2010110 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5]]},"reference":[{"issue":"2","key":"e_1_2_8_2_1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.tins.2010.12.001","article-title":"Astrocyte?neuron metabolic relationships: for better and for worse","volume":"34","author":"Allaman I.","year":"2011","journal-title":"Trends Neurosci."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22658"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21008"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpc.12068"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1992.tb00697.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.1995.12.1"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-10-04181.1993"},{"issue":"1","key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.2353\/ajpath.2008.070648","article-title":"Egr\u20101 regulates expression of the glial scar component phosphacan in astrocytes after experimental stroke","volume":"173","author":"Beck H.","year":"2008","journal-title":"Am. 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