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Fourteen healthy male Sprague\u2010Dawley newborn rats were randomly divided into 2 groups (n = 7 per group). Optic nerve transection was performed in the 7 rats of Group A three weeks after birth to obtain binocularly blind models, and the 7 rats of Group B were maintained as the control group. The VEP was measured to ensure complete binocular blindness. Four months after the operation, MnCl<jats:sub>2<\/jats:sub> was injected into the left inner ear perilymph of all rats, and an MRI examination was performed 24 h after injection. Then, ABR and AVR were measured to detect the generation of auditory compensatory function. The results of the VEP have confirmed complete binocular blindness. The normalized signal intensity of the bilateral medial geniculate nucleus, auditory cortex, visual center (including the lateral geniculate nucleus, superior colliculus and visual cortex) and right hippocampus in binocularly blind rats was significantly increased compared with that in normal rats (P \u2264 0.005), which was confirmed by measurement of the ABR and AVR. Our results suggested that MEMRI combined with electrophysiology can show changes in the auditory and visual pathways of binocularly blind rats and demonstrate the generation of an auditory compensatory pathway.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2017.05.002","type":"journal-article","created":{"date-parts":[[2017,5,21]],"date-time":"2017-05-21T14:00:16Z","timestamp":1495375216000},"page":"12-20","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Manganese\u2010enhanced MR imaging (MEMRI) combined with electrophysiology in the study of cross\u2010modal plasticity in binocularly blind rats"],"prefix":"10.1002","volume":"61","author":[{"given":"Zuohua","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Radiology Eye &amp; ENT Hospital of Shanghai Medical School, Fudan University Shanghai 200031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingjie","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Eye &amp; ENT Hospital of Shanghai Medical School, Fudan University Shanghai 200031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zebin","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Radiology Eye &amp; ENT Hospital of Shanghai Medical School, Fudan University Shanghai 200031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinghuai","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Eye &amp; ENT Hospital of Shanghai Medical School, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University Shanghai 200031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyuan","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Radiology Huashan Hospital of Shanghai Medical School, Fudan University Shanghai 200040 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Eye &amp; ENT Hospital of Shanghai Medical School, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University Shanghai 200031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiawen","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Eye &amp; ENT Hospital of Shanghai Medical School, State Key Laboratory of Medical Neurobiology, Institutes of Brain Science, Fudan University Shanghai 200031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy Eye &amp; ENT Hospital of Shanghai Medical School, Fudan University Shanghai 200031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wentao","family":"Wang","sequence":"additional","affiliation":[{"name":"Central Laboratory, Eye &amp; ENT Hospital of Shanghai Medical School, Fudan University Shanghai 200031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfeng","family":"Luo","sequence":"additional","affiliation":[{"name":"Health Statistics, Shanghai Medical School, Fudan University Shanghai 200031 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lixin","family":"Jin","sequence":"additional","affiliation":[{"name":"Siemens Ltd. 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