{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T17:00:54Z","timestamp":1759683654591,"version":"3.41.0"},"reference-count":70,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T00:00:00Z","timestamp":1497830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Turkish Scientific and Technical Council (TUBITAK)","award":["SBAG-107S069"],"award-info":[{"award-number":["SBAG-107S069"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Alcohol is one of the most commonly used drugs of abuse negatively affecting human health and it is known as a potent teratogen responsible for fetal alcohol syndrome (FAS), which is characterized by cognitive deficits especially pronounced in juveniles but ameliorating in adults. Searching for the potential morphological correlates of these effects, in this study, we compared the course of developmental changes in the morphology of principal hippocampal neurons in fetal\u2010alcohol (A group), intubated control (IC group), and intact control male rats (C group) over a protracted period of the first two postnatal months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ethanol was administered to the pregnant Wistar dams intragastrically, throughout gestation days (GD) 7\u201320, at a total dose of 6 g\/kg\/day resulting in the mean blood alcohol concentration (BAC) of 246.6 \u00b1 40.9 mg\/dl. Ten morphometric parameters of Golgi\u2010stained hippocampal neurons (pyramidal and granule) from CA1, CA3, and DG areas were examined at critical postnatal days (PD): at birth (PD1), at the end of the brain growth spurt period (PD10), in juveniles (PD30), and in young adults (PD60).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During postnatal development, the temporal pattern of morphometric changes was shown to be region\u2010dependent with most significant alterations observed between PD1\u201030 in the CA region and between PD10\u201030 in the DG region. It was also parameter\u2010dependent with the soma size (except for CA3 pyramids), number of primary dendrites, dendrite diameter, dendritic tortuosity and the branch angle demonstrating little changes, while the total dendritic field area, dendritic length, number of dendritic bifurcations, and spine density being highly increased in all hippocampal regions during the first postnatal month. Moderate ethanol intoxication and the maternal intubation stress during gestation, showed similar, transient effects on the neuron development manifested as a smaller soma size in granule cells, reduced dendritic parameters and lower spine density in pyramidal neurons at PD1. Full recovery from these effects took place within the first 10 postnatal days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study showed regional and temporal differences in the development of different morphometric features of principal hippocampal neurons in intact subjects over a protracted 2\u2010months postnatal period. It also demonstrated an overlap in the effects of a moderate fetal ethanol intoxication and a mild maternal stress produced by the intragastric intubation, a commonly used method of ethanol administration to the pregnant dams. Fast recovery from the adverse effects on the soma size, dendritic arborization and spines density observed at birth indicates towards the fetal ethanol\/stress induced developmental retardation.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijdevneu.2017.06.002","type":"journal-article","created":{"date-parts":[[2017,6,20]],"date-time":"2017-06-20T09:33:47Z","timestamp":1497951227000},"page":"40-50","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Effects of prenatal binge\u2010like ethanol exposure and maternal stress on postnatal morphological development of hippocampal neurons in rats"],"prefix":"10.1002","volume":"61","author":[{"given":"Ewa","family":"Jakubowska\u2010Dogru","sequence":"first","affiliation":[{"name":"Middle East Technical University Faculty of Science and Arts, Department of Biological Sciences Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birsen","family":"Elibol","sequence":"additional","affiliation":[{"name":"Bezmialem Vakif University, Faculty of Medicine Department of Medical Biology Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilknur","family":"Dursun","sequence":"additional","affiliation":[{"name":"Istanbul Kemerburgaz University, Faculty of Medicine Department of Physiology Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinan","family":"Y\u00fcr\u00fcker","sequence":"additional","affiliation":[{"name":"Hacettepe University, Faculty of Medicine Department of Histology and Embryology Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,6,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145705005286"},{"issue":"1","key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3109\/10408363.2011.580567","article-title":"Molecular and behavioral aspects of the actions of alcohol on the adult and developing brain","volume":"48","author":"Alfonso\u2010Loeches S.","year":"2011","journal-title":"Crit. 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