{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:15:31Z","timestamp":1786990531750,"version":"build-2736575974"},"reference-count":63,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T00:00:00Z","timestamp":1499904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Brain specific\u2010proteins are not found in other tissues and measurement non\u2010invasively in the blood may identify structurally and functionally damaged brain regions and identify the severity and prognosis of neuropsychiatric diseases. For this reason, we aimed to evaluate serum brain\u2010specific protein values as brain damage markers in children with autism spectrum disorder (ASD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>35 children with ASD and 31 healthy subjects were included in the study. Sociodemographic form and Childhood Autism Rating Scale (CARS) were applied to each subject. Serum neuron specific enolase (NSE), S100B, Myelin basic protein (MBP) and Glial fibrillary acidic protein (GFAP) values \u200b\u200bwere measured with ELISA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>There was no significant difference between the two groups for NSE, MBP and S100 B values (p = 0.242; p = 0.768; p = 0.672, respectively). However, GFAP values \u200b\u200bin the patient group were statistically significantly higher (mean \u00b1 SD: 0.463 \u00b1 0.392 ng\/ml) than in the healthy control group (mean \u00b1 SD: 0.256 \u00b1 0.111 ng\/ml) (p &lt; 0.001). In addition, there was a significant positive correlation between serum GFAP values \u200b\u200band CARS score in all subjects and in the patient group (r = 0.599; p &lt; 0.001 and r = 0.380; p = 0.024, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While serum NSE, MBP, and S100 B values cannot be considered as biomarkers for ASD, GFAP may be a biomarker and is suggested as a possible indicator of autism severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijdevneu.2017.06.011","type":"journal-article","created":{"date-parts":[[2017,7,13]],"date-time":"2017-07-13T06:16:57Z","timestamp":1499926617000},"page":"86-91","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Evaluation of serum Neuron\u2010specific enolase, S100B, myelin basic protein and glial fibrilliary acidic protein as brain specific proteins in children with autism spectrum disorder"],"prefix":"10.1002","volume":"61","author":[{"given":"Erman","family":"Esnafoglu","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Training and Research Hospital Faculty of Medicine Ordu University Ordu Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sema Nur","family":"Ayy\u0131ld\u0131z","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Training and Research Hospital Faculty of Medicine Ordu University Ordu Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selma","family":"C\u0131rr\u0131k","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology, Faculty of Medicine Ordu University Ordu Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emine Yurdakul","family":"Erturk","sequence":"additional","affiliation":[{"name":"Department of Pediatry Training and Research Hospital Faculty of Medicine Ordu University Ordu Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Erdil","sequence":"additional","affiliation":[{"name":"Department of Pediatry Training and Research Hospital Faculty of Medicine Ordu University Ordu Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Dagl\u0131","sequence":"additional","affiliation":[{"name":"Department of Pediatry Training and Research Hospital Faculty of Medicine Ordu University Ordu Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tevfik","family":"Noyan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Training and Research Hospital Faculty of Medicine Ordu University Ordu Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,13]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"APA","year":"2013"},{"issue":"10","key":"e_1_2_7_3_1","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/0006-3223(93)90124-V","article-title":"Glial fibrillary acidic protein in the cerebrospinal fluid of children with autism and other neuropsychiatric disorders","volume":"33","author":"Ahls\u00e9n G.","year":"1993","journal-title":"Biol. 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