{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:32:01Z","timestamp":1789612321390,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T00:00:00Z","timestamp":1499990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Health and Medical Research Council of Australia","award":["APP1002118"],"award-info":[{"award-number":["APP1002118"]}]},{"name":"Advance Queensland Research Fellowship"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Epidemiological evidence suggests that developmental vitamin D (DVD) deficiency is a risk factor for neuropsychiatric disorders, such as schizophrenia. DVD deficiency in rats is associated with altered brain structure and adult behaviours indicating alterations in dopamine and glutamate signalling. Developmental alterations in dopamine neurotransmission have also been observed in DVD\u2010deficient rats but a comprehensive assessment of brain neurochemistry has not been undertaken. Thus, the current study determined the regional concentrations of dopamine, noradrenaline, serotonin, glutamine, glutamate and \u03b3\u2010aminobutyric acid (GABA), and associated metabolites, in DVD\u2010deficient neonates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sprague\u2010Dawley rats were fed a vitamin D deficient diet or control diet six weeks prior to mating until birth and housed under UVB\u2010free lighting conditions. Neurotransmitter concentration was assessed by high\u2010performance liquid chromatography on post\u2010mortem neonatal brain tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ubiquitous reductions in the levels of glutamine (12\u201324%) were observed in DVD\u2010deficient neonates compared with control neonates. Similarly, in multiple brain regions DVD\u2010deficient neonates had increased levels of noradrenaline and serine compared with control neonates. In contrast, increased levels of dopamine and decreased levels of serotonin in DVD\u2010deficient neonates were limited to striatal subregions compared with controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results confirm that DVD deficiency leads to changes in multiple neurotransmitter systems in the neonate brain. Importantly, this regionally\u2010based assessment in DVD\u2010deficient neonates identified both widespread neurotransmitter changes (glutamine\/noradrenaline) and regionally selective neurotransmitter changes (dopamine\/serotonin). Thus, vitamin D may have both general and local actions depending on the neurotransmitter system being investigated. Taken together, these data suggest that DVD deficiency alters neurotransmitter systems relevant to schizophrenia in the developing rat brain.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijdevneu.2017.07.002","type":"journal-article","created":{"date-parts":[[2017,7,15]],"date-time":"2017-07-15T05:00:56Z","timestamp":1500094856000},"page":"1-7","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Developmental vitamin D deficiency alters multiple neurotransmitter systems in the neonatal rat brain"],"prefix":"10.1002","volume":"62","author":[{"given":"James P.","family":"Kesby","sequence":"first","affiliation":[{"name":"Queensland Brain Institute, The University of Queensland QLD St Lucia 4072 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karly M.","family":"Turner","sequence":"additional","affiliation":[{"name":"Queensland Brain Institute, The University of Queensland QLD St Lucia 4072 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Alexander","sequence":"additional","affiliation":[{"name":"Queensland Centre for Mental Health Research Wacol QLD 4076 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darryl W.","family":"Eyles","sequence":"additional","affiliation":[{"name":"Queensland Brain Institute, The University of Queensland QLD St Lucia 4072 Australia"},{"name":"Queensland Centre for Mental Health Research Wacol QLD 4076 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"McGrath","sequence":"additional","affiliation":[{"name":"Queensland Brain Institute, The University of Queensland QLD St Lucia 4072 Australia"},{"name":"Queensland Centre for Mental Health Research Wacol QLD 4076 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas H.J.","family":"Burne","sequence":"additional","affiliation":[{"name":"Queensland Brain Institute, The University of Queensland QLD St Lucia 4072 Australia"},{"name":"Queensland Centre for Mental Health Research Wacol QLD 4076 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,14]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Atlas of Prenatal Rat Brain Development","author":"Altman J.","year":"1995"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.03913.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2004.03.023"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2006.07.015"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-015-4192-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2010.04.005"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo-122-4-1224"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2010.09.057"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.01.035"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend.16.7.0866"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0301-0082(90)90013-7"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(03)00040-X"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2004.08.006"},{"key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/978-1-61779-157-4_5","volume-title":"Animal Models of Schizophrenia and Related Disorders","author":"Eyles D.W.","year":"2011"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.11.13.1961"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2012.12.001"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2003.09.004"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2015.00202"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/80.6.1678S"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)00409-X"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490410514"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.02.033"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.05.070"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-009-1717-y"},{"key":"e_1_2_7_26_1","article-title":"The effects of vitamin D on brain development and adult brain function","author":"Kesby J.P.","year":"2011","journal-title":"Mol. Cell. Endocrinol."},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2492-0"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2013.00111"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0893-133X(94)00131-I"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(01)00243-3"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.110"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1996.66010386.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2006.12.006"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(92)90141-N"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00272-2"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-268342"},{"key":"e_1_2_7_37_1","doi-asserted-by":"crossref","DOI":"10.1007\/s00429-016-1192-2","article-title":"Individual behavioral and neurochemical markers of unadapted decision\u2010making processes in healthy inbred mice","author":"Pittaras E.","year":"2016","journal-title":"Brain Struct. Funct."},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-0618(99)00002-2"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0074-7742(05)64003-2"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1136(199709)21:1<56::AID-GLIA6>3.0.CO;2-#"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(92)90032-7"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-6606-3-15"},{"key":"e_1_2_7_43_1","first-page":"39","article-title":"D\u2010serine as a gliotransmitter and its roles in brain development and disease","volume":"7","author":"Van Horn M.R.","year":"2013","journal-title":"Front. Cell. Neurosci."},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00565-4"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.2.888"}],"container-title":["International Journal of Developmental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736574817301491?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736574817301491?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijdevneu.2017.07.002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2017.07.002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.ijdevneu.2017.07.002","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2017.07.002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T18:07:51Z","timestamp":1694023671000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.ijdevneu.2017.07.002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,14]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1016\/j.ijdevneu.2017.07.002"],"URL":"https:\/\/doi.org\/10.1016\/j.ijdevneu.2017.07.002","archive":["Portico"],"relation":{},"ISSN":["0736-5748","1873-474X"],"issn-type":[{"value":"0736-5748","type":"print"},{"value":"1873-474X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,14]]},"assertion":[{"value":"2017-05-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}