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Acetylcholine is a neurotransmitter in the central nervous system and cholinesterase inhibitors have demonstrated a positive action over HI induced deficits. In order to evaluate the effects of pre and post\u2010hypoxia administrations of galantamine, a cholinesterase inhibitor, in a model of perinatal HI, Wistar rats in the post\u2010natal day 7 (PND7) were subjected to a combination of unilateral occlusion of the right carotid artery with the exposure to a 1 h hypoxia. Intraperitoneal injections of galantamine were administered in two different protocols: one pre and other post\u2010hypoxia. The analysis of brain structures volume at PND45 showed that pre\u2010hypoxia galantamine treatment prevented tissue injury to the ipsilesional hippocampus. Also, immunofluorescence showed HI\u2010induced increase in the number of astrocytes that was prevented by pre\u2010hypoxia treatment. Biochemical analysis was performed in the ipsilesional hippocampus at PND8 and revealed that pre\u2010hypoxia galantamine treatment: 1) prevented the neuronal loss induced by HI; 2) reduced the HI\u2010induced hypertrophy of astrocytes; and 3) caused an increase in the activity of the anti\u2010oxidant enzyme catalase. Overall, treatment with galantamine was able to prevent the brain damage, increase the survival of neurons, reduce astrocytic reaction and increase the activity of the anti\u2010oxidant enzyme catalase in rats submitted to neonatal hypoxia ischemia.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2017.07.006","type":"journal-article","created":{"date-parts":[[2017,7,29]],"date-time":"2017-07-29T04:32:10Z","timestamp":1501302730000},"page":"15-24","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Galantamine administration reduces reactive astrogliosis and upregulates the anti\u2010oxidant enzyme catalase in rats submitted to neonatal hypoxia ischemia"],"prefix":"10.1002","volume":"62","author":[{"given":"F.K.","family":"Odorcyk","sequence":"first","affiliation":[{"name":"Post\u2010graduation Program of Neurosciences Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade Universidade Federal do Rio Grande do Sul 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