{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T14:35:53Z","timestamp":1783953353561,"version":"3.55.0"},"reference-count":80,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,3,20]],"date-time":"2018-03-20T00:00:00Z","timestamp":1521504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Modafinil is a psychostimulant drug prescribed for treatment of narcolepsy. However, it is used as a \u201csmart drug\u201d especially by young adults to increase wakefulness, concentration and mental performance. Therefore, it can also be used by women with childbearing potential and its developmental effects can become a concern. The aim of this study was to assess behavioural and immune effects of prenatal modafinil exposure in mice and to evaluate the reaction to methamphetamine exposure on these animals in adult age.<\/jats:p><jats:p>Pregnant female mice were given either saline or modafinil (50\u202fmg\/kg orally) from gestation day (GD) 3 to GD 10 and then a challenge dose on GD 17. The male offspring were treated analogously at the age of 10 weeks with methamphetamine (2.5\u202fmg\/kg orally). Changes in the spontaneous locomotor\/exploratory behaviour and anxiogenic profile in the open field test were assessed in na\u00efve animals, after an acute and 8th modafinil dose and the challenge dose following a 7\u2010day wash\u2010out period. One month after completion of the behavioural study, the leukocyte phagocytosis was examined by zymosan induced and luminol\u2010aided chemiluminiscence assay <jats:italic>in vitro.<\/jats:italic><\/jats:p><jats:p>The modafinil prenatally exposed mice showed basal hypolocomotion, increased anxiety, lower locomotor effect of acute methamphetamine and increased vulnerability to behavioural sensitization. The leukocyte activity did not show significant differences.<\/jats:p><jats:p>Prenatal modafinil exposure alters basal behavioural profile, decreases acute effect of methamphetamine and enhances vulnerability to development of behavioural sensitization at adulthood. This may lead to higher vulnerability to development of addiction.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2018.03.005","type":"journal-article","created":{"date-parts":[[2018,3,20]],"date-time":"2018-03-20T22:50:56Z","timestamp":1521586256000},"page":"37-45","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prenatal exposure to modafinil alters behavioural response to methamphetamine in adult male mice"],"prefix":"10.1002","volume":"67","author":[{"given":"Jana","family":"Ruda\u2010Kucerova","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine Masaryk University Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Pistovcakova","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine Masaryk University Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra","family":"Amchova","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine Masaryk University Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Sulcova","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine Masaryk University Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alena","family":"Machalova","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine Masaryk University Brno Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2009.09.031"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/NSS.S103467"},{"key":"e_1_2_8_4_1","unstructured":"Administration A.G.D. of H.T.G. 2017.Prescribing medicines in pregnancy database [WWW Document].Ther. Goods Adm. TGA. URLhttps:\/\/www.tga.gov.au\/prescribing\u2010medicines\u2010pregnancy\u2010databas e. (Accessed 2.6.18)."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263\u2010016\u20100337\u20104"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.116.236000"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2009.06.012"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13181\u2010010\u20100017\u20106"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007380.pub4"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12055"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149\u20107634(01)00011\u20102"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devbrainres.2003.10.006"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920\u2010014\u20100524\u20102"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12821"},{"key":"e_1_2_8_15_1","unstructured":"EMA.Assessment Report for Modafinil Containing Medicinal Products.2016"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1017\/neu.2015.16"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.14712\/23362936.2015.43"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920\u2010015\u20100626\u20105"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028\u20103908(99)00181\u20101"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000085997"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0892-0362(92)90020-B"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2011.08.016"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.5620\/eht.2012.27.e2012007"},{"key":"e_1_2_8_24_1","first-page":"2","article-title":"Gender differences in cannabinoid and ecstasy interacting effects in mice","volume":"44","author":"Kucerova J.","year":"2006","journal-title":"Homeost. Health Dis."},{"key":"e_1_2_8_25_1","first-page":"663","article-title":"Impact of repeated methamphetamine pretreatment on intravenous self\u2010administration of the drug in males and estrogenized or non\u2010 estrogenized ovariectomized female rats","volume":"30","author":"Kucerova J.","year":"2009","journal-title":"Neuroendocrinol. Lett."},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145711001684"},{"key":"e_1_2_8_27_1","first-page":"703","article-title":"Impact of cannabinoid receptor ligands on behavioural sensitization to antiaggressive methamphetamine effects in the model of mouse agonistic behaviour","volume":"27","author":"Landa L.","year":"2006","journal-title":"Neuro Endocrinol. Lett."},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.2754\/avb200877020183"},{"key":"e_1_2_8_29_1","first-page":"2","article-title":"The change of behavioural methamphetamine effect after repeated MDMA administration in mice","volume":"51","author":"Landa L.","year":"2009","journal-title":"Act Nerv Super Rediviva"},{"key":"e_1_2_8_30_1","first-page":"841","article-title":"Altered cannabinoid CB1 receptor mRNA expression in mesencephalon from mice exposed to repeated methamphetamine and methanandamide treatments","volume":"32","author":"Landa L.","year":"2011","journal-title":"Neuro Endocrinol. Lett."},{"key":"e_1_2_8_31_1","first-page":"446","article-title":"Altered dopamine D1 and D2 receptor mRNA expression in mesencephalon from mice exposed to repeated treatments with methamphetamine and cannabinoid CB1 agonist methanandamide","volume":"33","author":"Landa L.","year":"2012","journal-title":"Neuro Endocrinol. Lett."},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.02.028"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/164_2017_36"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2013.05.038"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1159\/000104864"},{"key":"e_1_2_8_36_1","first-page":"101","article-title":"Pharmacokinetics\u2013pharmacodynamics of modafinil in mice","volume":"47","author":"Ma Z.\u2010Q.","year":"2012","journal-title":"Yao Xue Xue Bao"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-977X(10)70370-9"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2012.04.013"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.04.040"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2016.04.001"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2014.11.005"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.10.069"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2015.08.006"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2014.11.021"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2015.12.003"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2014.03.005"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-977X(12)70636-3"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278\u20105846(02)00250\u20106"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(92)90012-B"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2010.03.006"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2014.04.002"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20102007\u2010993212"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.09m05171bro"},{"key":"e_1_2_8_54_1","unstructured":"M.A.Hill.Embryology Rat Timeline.2018 Retrieved fromhttps:\/\/embryology.med.unsw.edu.au\/embryology\/index.php\/Rat_Timeline"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088\u2010200342020\u201000002"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00431451"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.84.6.1098"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2015.00091"},{"key":"e_1_2_8_59_1","article-title":"Prenatal exposure to modafinil alters locomotor behaviour and leucocyte phagocytosis in mice","author":"Ruda\u2010Kucerova J.","year":"2017","journal-title":"Psychiatr Danub"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03033244"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.113.090118"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2009.12.004"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/0924-977X(95)80011-P"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.1996.tb00597.x"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-977X(10)70931-7"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.932926"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.07.001"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.33549\/physiolres.932357"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1432.045"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650802175595"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2006.01.027"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1097\/jcp.0b013e31802eb7ea"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2008.12.013"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2014.10.002"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2016.00779"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.351"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2013.00139"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2013.10.027"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.112.007054"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00420"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.23"}],"container-title":["International Journal of Developmental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736574818300121?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0736574818300121?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.ijdevneu.2018.03.005","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2018.03.005","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.ijdevneu.2018.03.005","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.ijdevneu.2018.03.005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T12:43:09Z","timestamp":1692621789000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.ijdevneu.2018.03.005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,20]]},"references-count":80,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1016\/j.ijdevneu.2018.03.005"],"URL":"https:\/\/doi.org\/10.1016\/j.ijdevneu.2018.03.005","archive":["Portico"],"relation":{},"ISSN":["0736-5748","1873-474X"],"issn-type":[{"value":"0736-5748","type":"print"},{"value":"1873-474X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,20]]},"assertion":[{"value":"2018-01-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}