{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:15:37Z","timestamp":1786990537977,"version":"build-2736575974"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T00:00:00Z","timestamp":1522281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Melatonin, which is an antioxidant and neuroprotective agent, can be an effective treatment for neurological disorders. We assessed the effect of melatonin administration on histological changes, antioxidant enzyme levels, and behavioral changes in a neonate mouse model of cortical malformation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Cortical malformation was induced by two injections of 15\u202fmg\/kg methylazoxymethanol (MAM) on gestational day 15 (E15). Pregnant Balb\/c mice were randomly divided into the following six groups: Control (CO), Melatonin (MEL), Luzindole (LUZ), MAM, MEL\u202f+\u202fMAM1 (co\u2010treatment), and MEL\u202f+\u202fMAM2 (pretreatment). Melatonin was intraperitoneally injected at a dose of 10\u202fmg\/kg daily (from E15 until delivery of from E6 for 20\u202fdays after delivery). On postnatal day 31, the activity and anxiety of mice were assessed by open field and elevated plus maze tests, respectively. Histopathological changes in the neonate cortex were studied using hematoxylin and eosin staining and neurofilament immunohistochemistry. Enzyme\u2010linked immunosorbent assays were used to measure the activity of nitric oxide (NO), malondialdehyde (MDA), and antioxidant enzymes, including catalase (CAT), super oxide dismutase (SOD), and glutathione peroxidase (GPX).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In the behavioral assessment of neonate mice, a significant increase in the crossing activity and decrease in anxiety were recorded in groups treated with MAM plus melatonin. In histological examination, heterotopic, dysmorphic, and ectopic cells, as well as dyslamination, were seen in the MAM and LUZ groups. However, these defects were attenuated in the MAM plus melatonin groups. Significant reductions were recorded in the SOD and GPX levels in the MAM and LUZ groups compared to the control, while the NO level was increased in these groups. Groups that received MAM plus melatonin showed significant increases in the levels of SOD and GPX and a significant decrease in the level of NO, compared to the MAM group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Melatonin increased the crossing activity and decreased the anxiety in the treated mice of the neonate mouse model of cortical malformation. Histologically, the administration of exogenous melatonin in pregnant mice and their neonates had a protective effect on the cerebral cortex of neonates. Also, this effect is elicited by decreasing NO and increasing antioxidative enzymes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.ijdevneu.2018.03.008","type":"journal-article","created":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T18:44:22Z","timestamp":1522349062000},"page":"1-9","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Therapeutic effect of perinatal exogenous melatonin on behavioral and histopathological changes and antioxidative enzymes in neonate mouse model of cortical malformation"],"prefix":"10.1002","volume":"68","author":[{"given":"Maryam","family":"Azizi","sequence":"first","affiliation":[{"name":"Department of Anatomical Sciences, Faculty of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parichehr","family":"Pasbakhsh","sequence":"additional","affiliation":[{"name":"Department of Anatomical Sciences, Faculty of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Alireza","family":"Nadji","sequence":"additional","affiliation":[{"name":"Virology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihan","family":"Pourabdollah","sequence":"additional","affiliation":[{"name":"Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tahmineh","family":"Mokhtari","sequence":"additional","affiliation":[{"name":"Research center of Nervous system stem cells Department of Anatomy School of Medicine, Semnan University of Medical Sciences Semnan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makan","family":"Sadr","sequence":"additional","affiliation":[{"name":"Virology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negar","family":"Omidi","sequence":"additional","affiliation":[{"name":"Tehran Heart Center, Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iraj Ragerdi","family":"Kashani","sequence":"additional","affiliation":[{"name":"Department of Anatomical Sciences, Faculty of Medicine Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adib","family":"Zendehdel","sequence":"additional","affiliation":[{"name":"Institute of Neuroanatomy, RWTH Aachen University Aachen Germany"},{"name":"Giulan Neuroscience Research Center Department of Anatomical Sciences, Faculty of Medicine Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,3,29]]},"reference":[{"key":"e_1_2_7_2_1","article-title":"Effect of heavy metal on malondialdehyde and advanced oxidation protein products cencentration a focus on arsenic, cadmium, and mercury","volume":"4","author":"Alfanie I.","year":"2015","journal-title":"J. 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