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The aim of the current study was to investigate their prevalence and correlates in healthy controls without family history of any mental disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>The study sample included 122 normal subjects (66 males and 56 females; aged 32.89\u202f\u00b1\u202f9.91\u202fyears old). The assessment included the Neurological Evaluation Scale (NES), and a number of scales assessing the subthreshold symptoms (MADRS, STAI) and functioning (GAF). Data on a number of socio\u2010demographic variables were also gathered. The statistical analysis included the development of basic statistics tables and the calculation of Pearson correlation coefficients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results of the current study suggest that more than half of the study sample manifested at least one NSS and approximately 5% more than four. Still, the reported prevalence and NES scores are lower form those reported in the literature probably because of the carefully selected study sample. There were no significant correlations between NSS and any socio\u2010demographic or clinical variable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The current study is the first to study NSS in subjects without family history of any mental disorder and reports the presence of frequent silent neurodevelopmental events in the general population, probably in the form of a neurodevelopmental variation and possibly a weak generic rather than specific risk factor.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijdevneu.2018.04.006","type":"journal-article","created":{"date-parts":[[2018,4,27]],"date-time":"2018-04-27T02:45:17Z","timestamp":1524797117000},"page":"59-65","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Prevalence and correlates of neurological soft signs in healthy controls without family history of any mental disorder: A neurodevelopmental variation rather than a specific risk factor?"],"prefix":"10.1002","volume":"68","author":[{"given":"Konstantinos N.","family":"Fountoulakis","sequence":"first","affiliation":[{"name":"3rd Department of Psychiatry School of Medicine, Aristotle University of Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Panagiotidis","sequence":"additional","affiliation":[{"name":"3rd Department of Psychiatry School of Medicine, Aristotle University of Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasilios","family":"Kimiskidis","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Neurophysiology, School of Medicine, Aristotle University of Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Nimatoudis","sequence":"additional","affiliation":[{"name":"3rd Department of Psychiatry School of Medicine, Aristotle University of Thessaloniki Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xenia","family":"Gonda","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy Semmelweis University Budapest Hungary"},{"name":"MTA\u2010SE Neuropsychopharmacology and Neurochemistry Research Group of the Hungarian Academy of Sciences and Semmelweis University Budapest Hungary"},{"name":"NAP\u2010A\u2010SE New Antidepressant Target Research Group, Semmelweis University Budapest Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,27]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Diagnostic and Statistical Manual of Mental Disorders \u2013 4th ed.Text Revision","author":"American Psychiatric Association","year":"2000"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.12.2337"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2014.00185"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbj037"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2007.01.018"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbi028"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pscychresns.2005.02.011"},{"issue":"3","key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0165-1781(89)90148-0","article-title":"The neurological evaluation scale (NES): a structured instrument for the assessment of neurological signs in schizophrenia","volume":"27","author":"Buchanan R.W.","year":"1989","journal-title":"Psychiatry Res."},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2008.01.005"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/00048674.2010.482920"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbv196"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2009.11.012"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbp011"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2004.09.002"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2006.03.022"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2007.04.002"},{"issue":"3","key":"e_1_2_10_18_1","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/00005053-197903000-00004","article-title":"Neurological soft signs and psychopathology. 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