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The knowledge about the physiopathological mechanisms involved in HI lesion have increased in recent years, however these findings have not been translated into clinical practice. Current therapeutic approaches remain limited; hypothermia, used only in term or near\u2010term infants, is the golden standard. Epidemiological evidence shows a link between adverse prenatal conditions and increased risk for diseases, health problems, and psychological outcomes later in life, what makes pregnancy a relevant period for preventing future brain injury. Here, we review experimental literature regarding preventive interventions used during pregnancy, i.e., previous to the HI injury, encompassing pharmacological, nutritional and\/or behavioral strategies. Literature review used PubMed database. A total of forty one studies reported protective properties of maternal treatments preventing perinatal hypoxia\u2010ischemia injury in rodents. Pharmacological agents and dietary supplementation showed mainly anti\u2010excitotoxicity, anti\u2010oxidant or anti\u2010apoptotic properties. Interestingly, maternal preconditioning, physical exercise and environmental enrichment seem to engage the same referred mechanisms in order to protect neonatal brain against injury. This construct must be challenged by further studies to clearly define the main mechanisms responsible for neuroprotection to be explored in experimental context, as well as to test their potential in clinical settings.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2018.06.004","type":"journal-article","created":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T23:08:50Z","timestamp":1529363330000},"page":"12-24","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Pregnancy as a valuable period for preventing hypoxia\u2010ischemia brain damage"],"prefix":"10.1002","volume":"70","author":[{"given":"C.A.","family":"Netto","sequence":"first","affiliation":[{"name":"Biochemistry Department Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul, UFRGS Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.F.","family":"Sanches","sequence":"additional","affiliation":[{"name":"Biochemistry Department Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul, UFRGS Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Odorcyk","sequence":"additional","affiliation":[{"name":"Biochemistry Department Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul, UFRGS Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.E.","family":"Duran\u2010Carabali","sequence":"additional","affiliation":[{"name":"Biochemistry Department Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade, Universidade Federal do Rio Grande do Sul, UFRGS Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.V.","family":"Sizonenko","sequence":"additional","affiliation":[{"name":"Division of Child Development and Growth, Department of Pediatrics University of Geneva Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1329.054"},{"key":"e_1_2_8_3_1","first-page":"233","article-title":"Prenatal exposure to maternal voluntary exercise during pregnancy provides protection against mild chronic postnatal hypoxia in rat offspring","volume":"25","author":"Akhavan M.M.","year":"2012","journal-title":"Pak. 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