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Offspring <jats:italic>in utero<\/jats:italic>\u2010exposed to GBS\u2010induced placental inflammation displayed sex\u2010specific forebrain injuries. Sex differences have been reported in several neuropsychiatric disorders. Hence, we hypothesized that female rats <jats:italic>in utero<\/jats:italic>\u2010exposed to GBS may present sex\u2010specific neurobehavioral impairments. Lewis rats were injected intraperitoneally every 12\u202fh from gestational day (G) 19 to G22 with either saline (controls) or inactivated serotype Ia GBS (10<jats:sup>9<\/jats:sup> CFU). Before puberty, no difference in terms of spontaneous motor activity, exploratory or anxiety\u2010related behaviors was noticed between experimental conditions. During puberty, GBS\u2010exposed females \u2013 but not males \u2013 performed worse than same\u2010sex controls in a forced motor task. During adulthood, GBS\u2010exposed females \u2013 but not males \u2013 displayed increased spontaneous locomotor activity and decreased inhibition. In conclusion, our findings show for the first time that adult females \u2013 but not males \u2013 <jats:italic>in utero\u2010<\/jats:italic>exposed to GBS\u2010induced inflammation presented a hyperactive and disinhibited phenotype emerging after puberty.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2018.06.005","type":"journal-article","created":{"date-parts":[[2018,6,18]],"date-time":"2018-06-18T23:08:28Z","timestamp":1529363308000},"page":"17-22","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Hyperactive behavior in female rats <i>in utero<\/i>\u2010exposed to group B <i>Streptococcus<\/i>\u2010induced inflammation"],"prefix":"10.1002","volume":"69","author":[{"given":"Marie\u2010Julie","family":"Allard","sequence":"first","affiliation":[{"name":"Department of pediatrics McGill University Montreal Quebec 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