{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T16:59:34Z","timestamp":1781024374448,"version":"3.54.1"},"reference-count":63,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,6,30]],"date-time":"2018-06-30T00:00:00Z","timestamp":1530316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Cognitive Science and Technologies Council","award":["4552"],"award-info":[{"award-number":["4552"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prenatal exposure to valproic acid (VPA) induces behavioral disorders and enhancement of oxido\u2010inflammatory stress in Autism Spectrum Disorders (ASDs). The aim of this study was to investigate the comparative effects of hesperetin (Hst) and nano\u2010hesperetin on social behavior deficits and oxido\u2010inflammatory indexes in prenatally valproic acid\u2010exposed rat offspring. Pregnant Wistar rats on embryonic day 0 (E0) were segregated into six groups; Group\u20101 served as vehicle, received distillated water orally (PO) from E1 until the end of lactation and saline intraperitoneally (i.p) on E12.5. Group\u20102 received sodium valproate (500\u202fmg\/kg in 0.9% saline, i.p) on E12.5 was considered as VPA\u2010exposed group, Group\u20103 to 6 were VPA\u2010exposed which received hesperetin and nano\u2010hesperetin (10 and 20\u202fmg\/kg\/day, PO) from E0 until the end of lactation respectively. Social interaction and open field tests were conducted on postnatal day 28 (PND 28) and PND 30, cerebral antioxidant enzymes activity and biochemical indexes, the level of inflammatory factors in plasma and histopathology of cerebellum were estimated on PND 28 and PND 30. Prenatal valproic acid\u2010exposed rat exhibited poor sociability and high level of anxiety\u2010like behaviors (<jats:italic>P<\/jats:italic>\u202f&lt;\u202f 0.05). In addition, increased level of oxidative stress and inflammation were found by determining different oxido\u2010inflammatory markers. Hesperetin and nano\u2010hesperetin treatment improved the behavioral disorder and reduced the oxidative stress in brain and significantly (p\u202f&lt;\u202f 0.05) plasma's inflammation indexes. In conclusion, it can be state that nano\u2010hesperetin exerts neuroprotective action in comparison with hesperetin and could be efficacious for treatment of VPA animal model of autism during pregnancy and lactation.<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2018.06.009","type":"journal-article","created":{"date-parts":[[2018,6,30]],"date-time":"2018-06-30T09:27:06Z","timestamp":1530350826000},"page":"80-87","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Hesperetin and it nanocrystals ameliorate social behavior deficits and oxido\u2010inflammatory stress in rat model of autism"],"prefix":"10.1002","volume":"69","author":[{"given":"Rashin","family":"Khalaj","sequence":"first","affiliation":[{"name":"Department of Biology, Faculty of Basic Sciences University of Mazandaran Babolsar Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akbar","family":"Hajizadeh Moghaddam","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Basic Sciences University of Mazandaran Babolsar Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahboobeh","family":"Zare","sequence":"additional","affiliation":[{"name":"Faculty of Herbs Amol University of Special Modern Technologies Amol Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,30]]},"reference":[{"issue":"2","key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1093\/toxsci\/kfr007","article-title":"Embryoprotective role of endogenous catalase in acatalasemic and human catalase\u2010expressing mouse embryos exposed in culture to developmental and phenytoin\u2010enhanced oxidative stress","volume":"120","author":"Abramov J.P.","year":"2011","journal-title":"Toxicol. 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