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The present study validated the effect of Fisetin on developmental MeHg exposure induced alterations in mitochondrial apoptotic pathway and Rho GTPase mRNA expressions in hippocampus of F<jats:sub>1<\/jats:sub> generation rats. Pregnant Wistar rats were grouped as Group I : administered with vehicle control, Group II: MeHg (1.5\u2009mg\/kg b.w), Group III: MeHg\u2009+\u2009Fisetin (10\u2009mg\/kg b.w), Group IV: MeHg\u2009+\u2009Fisetin (30\u2009mg\/kg b.w), Group V: MeHg\u2009+\u2009Fisetin (50\u2009mg\/kg b.w), Group VI: MeHg\u2009+\u2009Fisetin (70\u2009mg\/kg b.w), Group VII: Fisetin (30\u2009mg\/kg b.w) alone. Fisetin reduced mercury accumulation in offspring brain. In hippocampus, Fisetin preserved mitochondrial total thiol status, glutathione antioxidant system, mitochondrial metabolic integrity and respiratory chain activity. Fisetin ameliorated apoptotic signals by preventing Cytochrome c release, down regulating ERK 1\/2 and Caspase 3 gene expression. Fisetin also upregulated mRNA expressions of RhoA\/Rac1\/Cdc42 in hippocampus. Predominant effect of Fisetin was to reduce mercury accumulation in offspring brain there by diminishing the toxic effect of MeHg. Hence we showed that, gestational intake of Fisetin (30\u2009mg\/kg b.w.) impedes developmental MeHg neurotoxicity by regulating mitochondrial apoptotic and Rho GTPase signalling molecules and by reducing the mercury accumulation in hippocampus of F<jats:sub>1<\/jats:sub> generation rats<\/jats:p>","DOI":"10.1016\/j.ijdevneu.2018.07.002","type":"journal-article","created":{"date-parts":[[2018,7,20]],"date-time":"2018-07-20T23:28:10Z","timestamp":1532129290000},"page":"88-96","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Fisetin impedes developmental methylmercury neurotoxicity via downregulating apoptotic signalling pathway and upregulating Rho GTPase signalling pathway in hippocampus of F<sub>1<\/sub> generation rats"],"prefix":"10.1002","volume":"69","author":[{"given":"Sherin","family":"Jacob","sequence":"first","affiliation":[{"name":"Dr.ALMPG IBMS, University of Madras Taramani Campus Chennai 600113 Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumathi","family":"Thangarajan","sequence":"additional","affiliation":[{"name":"Dr.ALMPG IBMS, University of Madras Taramani Campus Chennai 600113 Tamil Nadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1979.02130020064013"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"236","DOI":"10.4103\/0973-8258.91233","article-title":"The ameliorative effect of fisetin, a bioflavonoid, on ethanol\u2010induced and pylorus ligation\u2010induced gastric ulcer in rats","volume":"5","author":"Amit K.","year":"2011","journal-title":"IJGP"},{"key":"e_1_2_8_5_1","doi-asserted-by":"crossref","first-page":"196","DOI":"10.2174\/1389450116666150804110049","article-title":"Is intake of flavonoid\u2010based food supplements during pregnancy safe for the developing child? 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