{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T01:41:53Z","timestamp":1785202913194,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T00:00:00Z","timestamp":1531785600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Intl J of Devlp Neuroscience"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Perinatal hypoxic\u2010ischemic (HI) insult is an important cause of brain injury in neonates. The development of novel treatment strategies for neonates with HI brain injury is urgently needed. Ginkgolide B (GB) is a main component of Ginkgo biloba extracts with a long history of use in traditional Chinese medicine. However, it is unknown whether GB could play a protective role in hypoxic stress in immature animals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using neonatal hypoxic\u2010ischemic (HI) brain injury model of rat pups, neurological score, infarct size, and brain edema were evaluated after HI injury. The activation of microglia and the production of IL\u20101\u03b2 and IL\u201018 were detected by immunohistochemistry and ELISA, respectively. A priming signal (NF\u2010\u03baB P65) and an activation signal (Caspase\u20101) of NLRP3 inflammasome activation were detected by western blot analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>GB administrated 30\u2009min prior to ischemia induction can improve neurological disorder, reduce infarct volume and alleviate cerebral edema. Compared with the HI groups, GB inhibited the activation of microglia and decreased the production of IL\u20101\u03b2 and IL\u201018 in neocortex. Furthermore, GB reduced NLRP3 expression mainly in microglia, and significantly inhibited the expression of Caspase\u20101 and the nuclear translocation of NF\u2010\u03baB P65, preventing NLRP3 inflammasome activation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>GB ameliorates hypoxic\u2010ischemic brain injury in the neonatal male rat<jats:italic>via<\/jats:italic>inhibiting NLRP3 inflammasome activation.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.ijdevneu.2018.07.004","type":"journal-article","created":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T12:16:05Z","timestamp":1531916165000},"page":"106-111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Ginkgolide B ameliorates NLRP3 inflammasome activation after hypoxic\u2010ischemic brain injury in the neonatal male rat"],"prefix":"10.1002","volume":"69","author":[{"given":"Aiming","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pediatrics The Second People's Hospital of Taizhou Affiliated to Yangzhou University Taizhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neonatology The International Peace Maternity &amp; Child Health Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics The Second People's Hospital of Taizhou Affiliated to Yangzhou University Taizhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,7,17]]},"reference":[{"issue":"2","key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/bpa.12476","article-title":"A brain in flame; Do inflammasomes and pyroptosis influence stroke pathology?","volume":"27","author":"Barrington J.","year":"2017","journal-title":"Brain Pathol."},{"issue":"3","key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/10590500701569414","article-title":"Ginkgo biloba leave extract: biological, medicinal, and toxicological effects","volume":"25","author":"Chan P.C.","year":"2007","journal-title":"J. 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